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Using high-throughput SNP technologies to study cancer

Oncogene volume 25, pages 1594–1601 (2006)Cite this article

Abstract

Identifying genes involved in the development of cancer is crucial to fully understanding cancer biology, for developing novel therapeutics for cancer treatment and for providing methods for cancer prevention and early diagnosis. The use of polymorphic markers, in particular single nucleotide polymorphisms (SNPs), promises to provide a comprehensive tool for analysing the human genome and identifying those genes and genomic regions contributing to the cancer phenotype. This review summarizes the various analytical methodologies in which SNPs are used and presents examples of how each of these methodologies have been used to locate genes and genomic regions of interest for various cancer types. Additionally many of the current SNP-analysing technologies will be reviewed with particular attention paid to the advantages and disadvantages of each and how each technology can be applied to the analysis of the genome for identifying cancer-related genes.

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Acknowledgements

JEL is funded by a grant from the CVS Corporation.

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Authors and Affiliations

  1. Cetek Corporation, Marlborough, MA, USA

    L J Engle

  2. Institute of Psychiatry, Kings College London, London, UK

    C L Simpson

  3. Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown, MA, USA

    J E Landers

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Engle, L., Simpson, C. & Landers, J. Using high-throughput SNP technologies to study cancer. Oncogene 25, 1594–1601 (2006). https://doi.org/10.1038/sj.onc.1209368

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