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Deregulation of cell-signaling pathways in HTLV-1 infection

Oncogene volume 24, pages 5965–5975 (2005)Cite this article

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) infection is associated with the clonal expansion and transformation of mature T lymphocytes. While the mechanisms involved are incompletely understood the viral regulatory protein Tax plays a central role in these processes. Recent studies employing genomic and proteomic approaches have demonstrated the marked complexity of gene deregulation associated with Tax expression and confirmed the remarkable pleiotropism of this protein as evidenced by the numerous Tax–cellular protein interactions in infected cells. In this review, we summarize the role of Tax in the deregulation of selected cellular-signaling pathways. Specifically, this has focused on the influence and interaction of Tax with the AP-1 and NF-AT transcription factors, PDZ domain-containing proteins, Rho-GTPases, and the Janus kinase/signal transducer and activator of transcription and transforming growth factor-β-signaling pathways. In addition to identifying the deregulation of events within these pathways, attempts have been made to highlight differences between HTLV-1 and -2, which may relate to differences in their pathogenic properties.

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References

  • Albrecht B, Collins ND, Burniston MT, Nisbet JW, Ratner L, Green PL and Lairmore MD . (2000). J. Virol., 74, 9828–9835.

  • Albrecht B, D'Souza CD, Ding W, Tridandapani S, Coggeshall KM and Lairmore MD . (2002). J. Virol., 76, 3493–3501.

  • Alexandre C, Charnay P and Verrier B . (1991). Oncogene, 6, 1851–1857.

  • Araujo A and Hall WW . (2004). Ann Neurol, 56, 10–19.

  • Arnulf B, Villemain C, Nicot E, Mordelet P, Charneau J, Kersaul Y, Zermati A, Mauviel A, Bazarbachi A and Hermine O . (2002). Blood, 100, 4129.

  • Arya SK, Wong-Staal F and Gallo RC . (1984). Science, 223, 1086–1087.

  • Azran I, Schavinsky-Khrapunsky Y and Aboud M . (2004). Retrovirology, 1, 20–44.

  • Basbous J, Arpin C, Gaudray G, Piechaczyk M, Devaux C and Mesnard JM . (2003). J. Biol. Chem., 278, 43620–43627.

  • Behrens A, Sabapathy K, Graef I, Cleary M, Crabtree GR and Wagner EF . (2001). Proc. Natl. Acad. Sci. USA, 98, 1769–1774.

  • Behrens A, Sibilia M and Wagner EF . (1999). Nat. Genet., 21, 326–329.

  • Bezprozvanny I and Maximov A . (2001). Proc. Natl. Acad. Sci. USA, 98, 787–789.

  • Bilder D, Li M and Perrimon N . (2000). Science, 289, 113–116.

  • Bilder D and Perrimon N . (2000). Nature, 403, 676–680.

  • Blot V, Delamarre L, Perugi F, Pham D, Benichou S, Benarous R, Hanada T, Chishti AH, Dokhelar MC and Pique C . (2004). J. Cell Sci., 117, 3983–3993.

  • Bromberg JF . (2001). Bioessays, 23, 161–169.

  • Buchwalter G, Gross C and Wasylyk B . (2004). Gene, 324, 1–14.

  • Cereseto A, Washington Parks R, Rivadeneira E and Franchini G . (1999). Oncogene, 18, 2441–2450.

  • Chai J and Tarnawski AS . (2002). J. Physiol. Pharmacol., 53, 147–157.

  • Chen IS, Quan SG and Golde DW . (1983). Proc. Natl. Acad. Sci. USA, 80, 7006–7009.

  • Collins ND, Newbound GC, Albrecht B, Beard JL, Ratner L and Lairmore MD . (1998). Blood, 91, 4701–4707.

  • Crabtree GR and Clipstone NA . (1994). Annu. Rev. Biochem., 63, 1045–1083.

  • Craven SE and Bredt DS . (1998). Cell, 93, 495–498.

  • Cross SL, Feinberg MB, Wolf JB, Holbrook NJ, Wong-Staal F and Leonard WJ . (1987). Cell, 49, 47–56.

  • Davis RJ . (2000). Cell, 103, 239–252.

  • De La Fuenta C, Deng L, Santiago F, Arce L, Wang L and Kashanchi F . (2000). Aids Res. Hum. Retroviruses, 16, 1695–1700.

  • del Pozo MA, Vicente-Manzanares M, Tejedor R, Serrador JM and Sanchez-Madrid F . (1999). Eur. J. Immunol., 29, 3609–3620.

  • Derse D, Mikovits J and Ruscetti F . (1997). Virology, 237, 123–128.

  • Ding W, Albrecht B, Kelley RE, Muthusamy N, Kim SJ, Altschuld RA and Lairmore MD . (2002). J. Virol., 76, 10374–10382.

  • Ding W, Kim SJ, Nair AM, Michael B, Boris-Lawrie K, Tripp A, Feuer G and Lairmore MD . (2003). J. Virol., 77, 11027–11039.

  • Endo K, Hirata A, Iwai K, Sakurai M, Fukushi M, Oie M, Higuchi M, Hall WW, Gejyo F and Fujii M . (2002). J. Virol., 76, 2648–2653.

  • Fabre S, Reynaud C and Jalinot P . (2000). Mol. Biol. Rep., 27, 217–224.

  • Fanning AS and Anderson JM . (1999). J. Clin. Invest., 103, 767–772.

  • Fujii M, Chuhjo T, Minamino T, Masaaki N, Miyamoto K and Seiki M . (1995a). Oncogene, 11, 7–14.

  • Fujii M, Iwai K, Oie M, Fukushi M, Yamamoto N, Kannagi M and Mori N . (2000). AIDS Res. Hum. Retroviruses, 16, 1603–1606.

  • Fujii M, Iwai K, Oie M, Fukushi M, Yamamoto N, Kannagi M and Mori N . (1992a). AIDS Res. Hum. Retroviruses, 16, 1603–1606.

  • Fujii M, Niki T, Mori T, Matsuda T, Matsui M, Nomura N and Seiki M . (1991). Oncogene, 6, 1023–1029.

  • Fujii M, Sassone-Corsi P and Verma IM . (1988). Proc. Natl. Acad. Sci. USA, 85, 8526–8530.

  • Fujii M, Tsuchiya H, Chuhjo T, Akizawa T and Seiki M . (1992b). Genes Dev., 6, 2066–2076.

  • Fujii M, Tsuchiya H, Meng X and Seiki M . (1995b). Intervirology, 38, 221–228.

  • Fung MM, Chu YL, Fink JL, Wallace A and McGuire KL . (2005). Oncogene Epub Feb 28, 2005.

  • Gardiol D, Kuhne C, Glaunsinger B, Lee SS, Javier R and Banks L . (1999). Oncogene, 18, 5487–5496.

  • Gauchat JF, Schlagenhauf E, Feng NP, Moser R, Yamage M, Jeannin P, Alouani S, Elson G, Notarangelo LD, Wells T, Eugster HP and Bonnefoy JY . (1997). Eur. J. Immunol., 27, 971–978.

  • Gaudray G, Gachon F, Basbous J, Biard-Piechaczyk M, Devaux C and Mesnard JM . (2002). J. Virol., 76, 12813–12822.

  • Glaunsinger BA, Lee SS, Thomas M, Banks L and Javier R . (2000). Oncogene, 19, 5270–5280.

  • Good L, Maggirwar SB, Harhaj EW and Sun SC . (1997). J. Biol. Chem., 272, 1425–1428.

  • Good L, Maggirwar SB and Sun SC . (1996). EMBO J., 15, 3744–3750.

  • Goode S and Perrimon N . (1997). Genes Dev., 11, 2532–2544.

  • Grassmann R, Berchtold S, Radant I, Alt M, Fleckenstein B, Sodroski JG, Haseltine WA and Ramstedt U . (1992). J. Virol., 66, 4570–4575.

  • Green PL and Chen ISY . (2001). Fields Virology, 4th edn. Knipe D, Howley P, Griffin D, Lamb R, Martin M and Straus S (eds). Lippincott Williams & Wilkins: Philadelphia, pp. 1941–1969.

    Google Scholar 

  • Grossman WJ, Kimata JT, Wong FH, Zutter M, Levy TT and Ratner L . (1995). Proc. Natl. Acad. Sci. USA, 92, 1057.

  • Harhaj EW, Good L, Xiao G and Sun SC . (1999). Oncogene, 18, 1341–1349.

  • Hinrichs SH, Nereberg M, Reynolds RK, Khoury G and Jay GA . (1987). Science, 237, 1340.

  • Hirata A, Higuchi M, Niinuma A, Ohashi M, Fukushi M, Oie M, Akiyama M, Tanaka Y, Gejyo F and Fujii M . (2004). Virology, 318, 327–336.

  • Hollsberg P, Ausubel LJ and Hafler DA . (1994). J. Immunol., 153, 566.

  • Hubbard GB, Mone JP, Allan JS, Davis III KJ, Leland MM, Banks PM and Smir B . (1993). Lab. Anim. Sci., 43, 301–309.

  • Ijichi S, Ramundo H, Takahashi H and Hall WW . (1992). J. Exp. Med., 176, 293.

  • Imada K and Leonard WJ . (2000). Mol. Immunol., 37, 1–11.

  • Ishidate T, Matsumine A, Toyoshima K and Akiyama T . (2000). Oncogene, 19, 365–372.

  • Iwai K, Mori N, Oie M, Yamamoto N and Fujii M . (2001). Virology, 279, 38–46.

  • Iwakura Y, Tosu M, Yoshida E, Saijo S, Nakayama YJ, Itagaki K, Asano M, Siomi H, Hatanaka M and Takeda T . (1995). Virus Genes, 9, 161–170.

  • Jain J, Loh C and Rao A . (1995). Curr. Opin. Immunol., 7, 333–342.

  • Jeang KT, Chiu R, Santos E and Kim SJ . (1991). Virology, 181, 218–227.

  • Jeang KT . (2001). Cytokine Growth Factor Rev., 12, 207–217.

  • Jeang KT, Giam C, Majone F and Aboud M . (2004). J. Biol. Chem., 279, 31991–31994.

  • Jelen F, Oleksy A, Smietana K and Otlewski J . (2003). Acta Biochem. Pol., 50, 985–1017.

  • Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS and Jeang KT . (1997). J. Biol. Chem., 272, 25816–25823.

  • Jones KS, Akel S, Petrow-Sadowski C, Huang Y, Bertolette DC and Ruscetti FW . (2005). J. Immunol., 174, 4262–4270.

  • Kim SJ, Kehrl JH, Burton CL, Tendler KT, Jeang D, Danielpour C, Thevenin C, Kim KY, Sporn B and Roberts AB . (1990). J. Exp. Med., 172, 121.

  • Kim SJ, Winokur TS, Lee HD, Danielpour D, Kim KY, Geiser AG, Chen LS, Sporn MB, Roberts AB and Jay G . (1991). Mol. Cell Biol., 11, 5222–5228.

  • Kiyono T, Hiraiwa A, Fujita M, Hayashi Y, Akiyama T and Ishibashi M . (1997). Proc. Natl. Acad. Sci. USA, 94, 11612–11616.

  • Lee C and Laimins LA . (2004). J. Virol., 78, 12366–12377.

  • Lee DK, Kim BC, Brady JN, Jeang KT and Kim SJ . (2002). J. Biol. Chem., 227, 33766–33775.

  • Lee SS, Glaunsinger B, Mantovani F, Banks L and Javier RT . (2000). J. Virol., 74, 9680–9693.

  • Lee SS, Weiss RS and Javier RT . (1997). Proc. Natl. Acad. Sci. USA, 94, 6670–6675.

  • Leonard WJ and O'Shea JJ . (1998). Annu. Rev. Immunol., 16, 293–322.

  • Lin JX and Leonard WJ . (2000). Oncogene, 19, 2566–2576.

  • Liu X, Chen X, Zachar V, Chang C and Ebbesen P . (1999). J. Gen. Virol., 80, 3073–3081.

  • Liu Y, Wang Y, Yamakuchi M, Masuda S, Tokioka T, Yamaoka S, Maruyama I and Kitajima I . (2001). Oncogene, 20, 2514–2526.

  • Loh C, Carew JA, Kim J, Hogan PG and Rao A . (1996). Mol. Cell Biol., 16, 3945–3954.

  • Mamane Y, Grandvaux N, Hernandez E, Sharma S, Innocente SA, Lee JM, Azimi N, Lin R and Hiscott J . (2002a). Oncogene, 21, 6751–6765.

  • Mamane Y, Sharma S, Grandvaux N, Hernandez E and Hiscott J . (2002b). J. Interferon Cytokine Res., 22, 135–143.

  • Mariner JM, Mamane Y, Hiscott J, Waldmann TA and Azimi N . (2002). J. Immunol., 168, 5667–5674.

  • Maruta H, He H, Tikoo A, Vuong T and Nur EKM . (1999). Microsc. Res. Tech., 47, 61–66.

  • Maruyama M, Shibuya H, Harada H, Hatakeyama M, Seiki M, Fujita T, Inoue J, Yoshida M and Taniguchi T . (1987). Cell, 48, 343–350.

  • Massimi P, Gammoh N, Thomas M and Banks L . (2004). Oncogene, 23, 8033–8039.

  • Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, Baeg GH, Kawahara T, Kobayashi S, Okada M and Toyoshima K . (1996). Science, 272, 1020–1023.

  • Matsumoto J, Ohshima T, Isono O and Shimotohno K . (2004). Oncogene, 24, 1001–1010.

  • Matsumoto K, Shibata H, Fujisawa JI, Inoue H, Hakura A, Tsukahara T and Fujii M . (1997). J. Virol., 71, 4445–4451.

  • Matsuoka M . (2003). Oncogene, 22, 5131–5140.

  • Migone TS, Lin JX, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G and Leonard WJ . (1995). Science, 269, 79–81.

  • Minty A, Asselin S, Bensussan A, Shire D, Vita N, Vyakarnam A, Wijdenes J, Ferrara P and Caput D . (1997). Eur. Cytokine Netw., 8, 203–213.

  • Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, Labit C, Leplatois P, Liauzun P, Miloux B, Minty C, Casellas P, Loison G, Lupker J, Shire D, Ferrara P and Caput D . (1993). Nature, 362, 248–250.

  • Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K and Hinuma Y . (1981). Nature, 294, 770–771.

  • Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R and Pledger WJ . (2003). Cancer Res., 63, 8523–8530.

  • Montaner S, Perona R, Saniger L and Lacal JC . (1998). J. Biol. Chem., 273, 12779–12785.

  • Mori N, Fujii M, Iwai K, Ikeda S, Yamasaki Y, Hata T, Yamada Y, Tanaka Y, Tomonaga M and Yamamoto N . (2000). Blood, 95, 3915–3921.

  • Mulloy JC, Migone TS, Ross TM, Ton N, Green PL, Leonard WJ and Franchini G . (1998). J. Virol., 72, 4408–4412.

  • Nagai M, Ijichi S, Hall WW and Osame M . (1995). Clin. Immunol. Immunopathol., 77, 324.

  • Nagata K, Ohtani K, Nakamura M and Sugamura K . (1989). J. Virol., 68, 3220–3226.

  • Nakagawa S and Huibregtse JM . (2000). Mol. Cell Biol., 20, 8244–8253.

  • Nakamura N, Fujii M, Tsukahara T, Arai M, Ohashi T, Kannagi M and Yamamoto N . (1999). Oncogene, 18, 2667–2675.

  • Nerenberg M, Hinrichs SH, Reynolds RK, Khoury G and Jay GA . (1987). Science, 237, 1324.

  • Ng PW, Iha H, Iwanaga Y, Bittner M, Chen Y, Jiang Y, Gooden G, Trent JM, Meltzer P, Jeang KT and Zeichner SL . (2001). Oncogene, 20, 4484–4496.

  • Niitsu Y, Urushizaki Y, Koshida Y, Terui K, Mahara K, Kohgo Y and Urushizaki I . (1988). Blood, 71, 263.

  • Ohashi M, Sakurai M, Higuchi M, Mori N, Fukushi M, Oie M, Coffey RJ, Yoshiura K, Tanaka Y, Uchiyama M, Hatanaka M and Fujii M . (2004). Virology, 320, 52–62.

  • Panting CP and Phillips C . (1995). Trends Biochem. Sci., 20, 102–103.

  • Park J, Yaseen NR, Hogan PG, Rao A and Sharma S . (1995). J. Biol. Chem., 270, 20653–20659; 10.1074.

  • Perrimon N . (1988). Dev. Biol., 127, 392–407.

  • Pim D, Thomas M, Javier R, Gardiol D and Banks L . (2000). Oncogene, 19, 719–725.

  • Pise-Masison CA, Radonovich M, Mahieux R, Chatterjee P, Whiteford C, Duvall J, Guillerm C, Gessain A and Brady JN . (2002). Cancer Res., 15, 3562–3571.

  • Rao A . (1994). Immunol. Today, 15, 274–281.

  • Reddy TR, Li X, Jones Y, Ellisman MH, Ching GY, Liem RK and Wong-Staal F . (1998). Proc. Natl. Acad. Sci. USA, 95, 702–707.

  • Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H and Glimcher LH . (2002). J. Exp. Med., 195, 1003.

  • Rivera I, Harhaj EW and Sun SC . (1998). J. Biol. Chem., 273, 22382–22388.

  • Robek MD and Ratner L . (1999). J. Virol., 73, 4856–4865.

  • Rousset R, Fabre S, Desbois C, Bantignies F and Jalinot P . (1998). Oncogene, 16, 643–654.

  • Ruff VA and Leach KL . (1995). J. Biol. Chem., 270, 22602–22607; 10.1074.

  • Sakamoto KM, Nimer SD, Rosenblatt JD and Gasson JC . (1992). Oncogene, 7, 2125–2130.

  • Salvetti A, Lilienbaum A, Portier MM, Gounon P, Paulin D and Gazzolo L . (1993). Eur. J. Cell Biol., 61, 383–391.

  • Schmitz P, Govak EE, Böttner B and Van Aelst L . (2000). Exp Cell Res., 261, 1–12.

  • Sharma S, Graandvaux N, Mamane Y, Genin P, Azimi N, Waldmann T and Hiscott J . (2002). J. Immunol., 169, 3120–3130.

  • Shaulian E and Karin M . (2002). Nat. Cell Biol., 4, E131–E136.

  • Shi Y and Massague J . (2003). Cell, 113, 685–700.

  • Shibasaki F, Price ER, Milan D and McKeon F . (1996). Nature, 382, 370–373.

  • Shuh M and Derse D . (2000). J. Virol., 74, 11394–11397.

  • Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM and Cantley LC . (1997). Science, 275, 73–77.

  • Stam JC, Michiels F, van der Kammen RA, Moolenaar WH and Collard JG . (1998). EMBO J., 17, 4066–4074.

  • Sun SC, Maggirwar SB, Harhaj EW and Uhlik M . (1999). Oncogene, 18, 1401–1409.

  • Suzuki T, Ohsugi Y, Uchida-Toita M, Akiyama T and Yoshida M . (1999). Oncogene, 18, 5967–5972.

  • Takatsuki K, Yamaguchi K, Kawano F, Hattori T, Nishimura H, Tsuda H, Sanada I, Nakada K and Itai Y . (1985). Cancer Res., 45, 4644S–4464S.

  • Takemoto S, Mulloy JC, Cereseto A, Migone TS, Patel BK, Matsuoka M, Yamaguchi K, Takatsuki K, Kamihira S, White JD, Leonard WJ, Waldmann T and Franchini G . (1997). Proc. Natl. Acad. Sci. USA, 94, 13897–13902.

  • Thebault S, Basbous J, Hivin P, Devaux C and Mesnard JM . (2004). FEBS Lett., 562, 165–170.

  • Thomas M, Laura R, Hepner K, Guccione E, Sawyers C, Lasky L and Banks L . (2002). Oncogene, 21, 5088–5096.

  • Trihn D, Jeang KT and Semmes OJ . (1997). J. Biomed. Sci., 4, 47–53.

  • Tsuboi K, Iida S, Inagaki H, Kato M, Hayami Y, Hanamura I, Miura K, Harada S, Kikuchi M, Komatsu H, Banno S, Wakita A, Nakamura S, Eimoto T and Ueda R . (2000). Leukemia, 14, 449.

  • Tsuchiya H, Fujii M, Niki T, Tokuhara M, Matsui M and Seiki M . (1993). J. Virol., 67, 7001–7007.

  • Uchijima M, Sato H, Fujii M and Seiki M . (1994). J. Biol. Chem., 269, 14946–14950.

  • Uchiyama T, Yodoi J, Sagawa K, Takatsuki K and Uchino H . (1977). Blood, 50, 481–492.

  • Voevodin A, Samilchuk E, Schatzl H, Boeri E and Franchini G . (1996). J. Virol., 70, 1633–1639.

  • Volkman DJ, Popovic M, Gallo RC and Fauci AS . (1985). J. Immunol., 134, 4237–4243.

  • Waldele K, Schneider G, Ruckes T and Grassmann R . (2004). J. Virol., 78, 6081–6090.

  • Wang TG, Ye J, Lairmore MD and Green PL . (2000). AIDS Res. Hum. Retroviruses, 16, 1661–1668.

  • Williams JG . (2000). Curr. Opin. Genet. Dev., 10, 503–507.

  • Wilson KC, Center DM, Cruikshank WW and Zhang Y . (2003). Virology, 1, 60–67.

  • Woods DF and Bryant PJ . (1991). Cell, 66, 451–464.

  • Woods DF, Hough C, Peel D, Callaini G and Bryant PJ . (1996). J. Cell Biol., 134, 1469–1482.

  • Wright K, Kolios G, Westwick J and Ward SG . (1999). J. Biol. Chem., 274, 17193–17201.

  • Wu K, Bottazi E, De la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A and Kashanchi F . (2004). J. Biol. Chem., 279, 495–508.

  • Xu X, Heidenreich O, Kitajima I, McGuire K, Li Q, Su B and Nerenberg M . (1996). Oncogene, 13, 135–142.

  • Xu X, Kang SH, Heidenreich O, Okerholm M, O'Shea JJ and Nerenberg MI . (1995). J. Clin. Invest., 96, 1548–1555.

  • Yamamoto N, Okada M, Koyanagi Y, Kannagi M and Hinuma Y . (1982). Science, 217, 737–739.

  • Yamaoka S, Courtois G, Bessia C, Whiteside ST, Weil R, Agou F, Kirk HE, Kay RJ and Israel A . (1998). Cell, 93, 1231–1240.

  • Yamaoka S, Inoue J, Sakurai M, Sugiyama T, Hazama M, Yamada T and Hatanaka M . (1996). EMBO J., 15, 873–887.

  • Yoshida M . (2001). Ann. Rev. Immunol., 19, 475–496.

  • Zhang Q, Lee B, Korecka M, Li G, Weyland C, Eck S, Gessain A, Arima N, Lessin SR, Shaw LM, Luger S, Kamoun M and Wasik MA . (1999). Leuk. Res., 4, 373–384.

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  1. Department of Medical Microbiology, Centre for Research in Infectious Diseases, University College Dublin, Belfield, 4, Dublin, Ireland

    William W Hall

  2. Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori Niigata, Niigata, 951-8510, Japan

    Masahiro Fujii

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Hall, W., Fujii, M. Deregulation of cell-signaling pathways in HTLV-1 infection. Oncogene 24, 5965–5975 (2005). https://doi.org/10.1038/sj.onc.1208975

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