Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Report
  • Published:

Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes

Oncogene volume 24, pages 5131–5136 (2005)Cite this article

Abstract

p63 and p73 show a high degree of structural homology to p53 and are members of a family of transcriptional factors that can activate transcription of p53-responsive genes. p53 is mutated in more than 50% of human cancers, whereas p63 and p73 are rarely mutated. Studies of knockout mice also revealed an unexpected functional diversity among the p53 family. To determine how p63 and p73 are involved in tumorigenesis and normal development, we used cDNA microarray to examine 9216 genes in human colorectal cancer cells. We discovered that the expression of pigment epithelium-derived factor (PEDF) was specifically induced by either p63 or p73, but not by p53. We also report here that the PEDF gene contains a response element specific for p63 and p73 in its promoter region and is a direct target of p63 and p73. Collectively, p63 and p73 may be involved in cell fate by inducing PEDF expression.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  • Becerra SP, Sagasti A, Spinella P and Notario V . (1995). J. Biol. Chem., 270, 25992–25999.

  • Billon N, Terrinoni A, Jolicoeur C, McCarthy A, Richardson WD, Melino G and Raff M . (2004). Development, 131, 1211–1220.

  • Carmeliet P and Jain RK . (2000). Nature, 407, 249–257.

  • Crawford SE, Stellmach V, Ranalli M, Huang X, Huang L, Volpert O, De Vries GH, Abramson LP and Bouck N . (2001). J. Cell Sci., 114, 4421–4428.

  • Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W and Bouck NP . (1999). Science, 285, 245–248.

  • De Laurenzi V, Raschella G, Barcaroli D, Annicchiarico-Petruzzelli M, Ranalli M, Catani MV, Tanno B, Costanzo A, Levrero M and Melino G . (2000a). J. Biol. Chem., 275, 15226–15231.

  • De Laurenzi V, Rossi A, Terrinoni A, Barcaroli D, Levrero M, Costanzo A, Knight RA, Guerrieri P and Melino G . (2000b). Biochem. Biophys. Res. Commun., 273, 342–346.

  • Dietz S, Rother K, Bamberger C, Schmale H, Mossner J and Engeland K . (2002). FEBS. Lett., 525, 93–99.

  • Doll JA, Stellmach VM, Bouck NP, Bergh AR, Lee C, Abramson LP, Cornwell ML, Pins MR, Borensztajn J and Crawford SE . (2003). Nat. Med., 9, 774–780.

  • Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery Jr CA, Butel JS and Bradley A . (1992). Nature, 356, 215–221.

  • El-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW and Vogelstein B . (1992). Nat. Genet., 1, 45–49.

  • El-Deiry WS . (1998). Semin. Cancer Biol., 8, 345–357.

  • Hainaut P, Soussi T, Shomer B, Hollstein M, Greenblatt M, Hovig E, Harris CC and Montesano R . (1997). Nucleic Acids Res., 25, 151–157.

  • Hollstein M, Soussi T, Thomas G, von Brevern MC and Bartsch . (1997). Recent Results Cancer Res., 143, 369–389.

  • Holmgren L, O'Reilly MS and Folkman J . (1995). Nat. Med., 1, 149–153.

  • Ishida S, Yamashita T, Nakaya U and Tokino T . (2000). Jpn. J. Cancer Res., 91, 174–180.

  • Jost CA, Marin MC and Kaelin Jr WG . (1997). Nature, 389, 191–194.

  • Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F and Caput D . (1997). Cell, 90, 809–819.

  • Melino G, De Laurenzi V and Vousden KH . (2002). Nat. Rev. Cancer, 2, 605–615.

  • Melino G, Lu X, Gasco M, Crook T and Knight RA . (2003). Trends Biochem. Sci., 28, 663–670.

  • Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR and Bradley A . (1999). Nature, 398, 708–713.

  • Morimoto I, Sasaki Y, Ishida S, Imai K and Tokino T . (2002). Genes Chromosomes Cancer, 33, 270–278.

  • Okabe H, Satoh S, Kato T, Kitahara O, Yanagawa R, Yamaoka Y, Tsunoda T, Furukawa Y and Nakamura Y . (2001). Cancer Res., 61, 2129–2137.

  • Ono K, Tanaka T, Tsunoda T, Kitahara O, Kihara C, Okamoto A, Ochiai K, Takagi T and Nakamura Y . (2000). Cancer Res., 60, 5007–5011.

  • Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M and Ikawa S . (1998). Nat. Med., 4, 839–843.

  • Prabhu NS, Somasundaram K, Satyamoorthy K, Herlyn M and El-Deiry WS . (1998). Int. J. Oncol., 13, 5–9.

  • Sasaki Y, Morimoto I, Ishida S, Yamashita T, Imai K and Tokino T . (2001). Gene Therapy, 8, 1401–1408.

  • Sasaki Y, Ishida S, Morimoto I, Yamashita T, Kojima T, Kihara C, Tanaka T, Imai K, Nakamura Y and Tokino T . (2002). J. Biol. Chem., 277, 719–724.

  • Sasaki Y, Mita H, Toyota M, Ishida S, Morimoto I, Yamashita T, Tanaka T, Imai K, Nakamura Y and Tokino T . (2003). Cancer Res., 63, 8145–8152.

  • Stellmach V, Crawford SE, Zhou W and Bouck N . (2001). Proc. Natl. Acad. Sci. USA, 98, 2593–2597.

  • Taniwaki T, Becerra SP, Chader GJ and Schwartz JP . (1995). J. Neurochem., 64, 2509–2517.

  • Tokino T and Nakamura Y . (2000). Crit. Rev. Oncol. Hematol., 33, 1–6.

  • Tombran-Tink J, Chader GG and Johnson LV . (1991). Exp. Eye Res., 53, 411–414.

  • van Bokhoven H and Mckeon F . (2002). Trends Mol. Med., 8, 133–139.

  • Vogelstein B, Lane D and Levine AJ . (2000). Nature, 408, 307–310.

  • Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D and McKeon F . (1998). Mol. Cell, 2, 305–316.

  • Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C and McKeon F . (1999). Nature, 398, 714–718.

  • Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, McKeon F and Caput D . (2000). Nature, 404, 99–103.

  • Yang A, Kaghad M, Caput D and McKeon F . (2002). Trends Genet., 18, 90–95.

  • Zheng X and Chen X . (2001). FEBS Lett., 489, 4–7.

Download references

Acknowledgements

We thank Dr Joseph F Costello for valuable discussion in this study. This study was supported in part by Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology (YS, KI and TT).

Author information

Author notes

  1. Yasushi Sasaki and Yasuyoshi Naishiro: These authors contributed equally to this work

Authors and Affiliations

  1. Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S-1, W-17, Chuo-ku, 060-8556, Sapporo, Japan

    Yasushi Sasaki, Yasuyoshi Naishiro, Yuichiro Oshima & Takashi Tokino

  2. First Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan

    Kohzoh Imai

  3. Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, 108-8639, Tokyo, Japan

    Yusuke Nakamura

Authors
  1. Yasushi Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasuyoshi Naishiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuichiro Oshima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kohzoh Imai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yusuke Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takashi Tokino
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takashi Tokino.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sasaki, Y., Naishiro, Y., Oshima, Y. et al. Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes. Oncogene 24, 5131–5136 (2005). https://doi.org/10.1038/sj.onc.1208695

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1208695

Keywords

This article is cited by

Search

Advanced search

Quick links