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New insights into cell cycle control from the Drosophila endocycle

Oncogene volume 24, pages 2765–2775 (2005)Cite this article

Abstract

During metazoan development, the organization of the cell cycle is often modified in response to developmental signals. The endocycle provides a dramatic example of this phenomenon. In the endocycle, also referred to as the endoreplicative cycle, cells undergo successive rounds of DNA replication without an intervening mitosis. Often the endocycle is used to expand the genome of a group of specialized cells that are highly biosynthetically active. In these circumstances, large polyploid cells are produced in organisms that are primarily comprised of diploid cells. However, many organisms achieve growth by increasing cell size, rather than cell number. This strategy is more generally exploited in insects and plants. For instance, in the insect Drosophila melanogaster, the majority of the larval tissues, as well as many adult tissues, enter the endocycle and become polyploid. Therefore, Drosophila has been a rich source for studies on endocycle regulation. Recent work from Drosophila is beginning to reveal how developmental signals promote the transition from the mitotic cycle to the endocycle, as well as what drives endocycle progression. In addition, studies on the endocycle have provided insight into the regulatory principles underlying the once per cell cycle replication of the genome, as well as the relationship between S phase and mitosis.

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Acknowledgements

We thank Tin Tin Su and Brian Calvi for helpful discussions. We thank Juan Riesgo Escovar for comments on the paper.

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Authors and Affiliations

  1. Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA

    Mary A Lilly

  2. Lineberger Comprehensive Cancer Center, Program in Molecular Biology and Biotechnology, and Department of Biology, University of North Carolina, Chapel Hill, NC, 27599, USA

    Robert J Duronio

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Correspondence to Mary A Lilly.

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Lilly, M., Duronio, R. New insights into cell cycle control from the Drosophila endocycle. Oncogene 24, 2765–2775 (2005). https://doi.org/10.1038/sj.onc.1208610

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