Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Report
  • Published:

Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus

Oncogene volume 24, pages 1958–1963 (2005)Cite this article

Abstract

Pas1 candidate 1 (Pas1c1) gene (also named Lmna-rs1) was found to encode two alternatively spliced mRNA transcripts (i.e. Pas1c1-Va and Pas1c1-Vb). In this study, we identified three additional mRNA transcripts encoded by the Pas1c1 gene, which were designated as Pas1c1-Vc, Pas1c1-Vd, and Pas1c1-Ve, respectively. Similar to Pas1c1-Vb, the newly identified transcripts were only expressed in mouse lung tissues from strains carrying the Pas1-susceptible (Pas1/s) allele. Pas1c1 transcripts were also detected in heart, testis, or brain but not in liver, spleen, or kidney. An 11-nucleotide polymorphism was found within the 3′-acceptor splice site of exon 8, which cosegregates with mouse strain Pas1 alleles and may underlie the strain-specific exon 8 skipping. We also found that ectopic expression of the Pas1c1-Va and Pas1c1-Vb in COS7 and NIH3T3 cells exhibited distinct intracellular distributions. These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  • Devereux TR, Wiseman RW, Kaplan N, Garren S, Foley JF, White CM, Anna C, Watson MA, Patel A and Jarchow S . (1994). Mamm. Genome, 5, 749–755.

  • Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW and Collins FS . (2003). Nature, 423, 293–298.

  • Favreau C, Higuet D, Courvalin JC and Buendia B . (2004). Mol. Cell. Biol., 24, 1481–1492.

  • Festing MF, Yang A and Malkinson AM . (1994). Genet. Res., 64, 99–106.

  • Gariboldi M, Manenti G, Canzian F, Falvella FS, Radice MT, Pierotti MA, Della Porta G, Binelli G and Dragani TA . (1993). Nat. Genet., 3, 132–136.

  • Lammerding J, Schulze PC, Takahashi T, Kozlov S, Sullivan T, Kamm RD, Stewart CL and Lee RT . (2004). J. Clin. Invest., 113, 370–378.

  • Lin L, Festing MF, Devereux TR, Crist KA, Christiansen SC, Wang Y, Yang A, Svenson K, Paigen B, Malkinson AM and You M . (1998). Exp. Lung Res., 24, 481–497.

  • Malkinson AM . (1989). Toxicology, 54, 241–271.

  • Manenti G, Falvella FS, Gariboldi M, Dragani TA and Pierotti MA . (1995). Genomics, 29, 438–444.

  • Manenti G, Galbiati F, Gianni-Barrera R, Pettinicchio A, Acevedo A and Dragani TA . (2004). Oncogene, 23, 4495–4504.

  • Minna JD, Roth JA and Gazdar AF . (2002). Cancer Cell, 1, 49–52.

  • Wang M, Lemon WJ, Liu G, Wang Y, Iraqi FA, Malkinson AM and You M . (2003). Cancer Res., 63, 3317–3324.

  • Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan KL and You M . (2003). Proc. Natl. Acad. Sci. USA, 100, 12642–12647.

Download references

Acknowledgements

This work was supported by NIH Grants R01CA58554 and R01ES012063.

Author information

Authors and Affiliations

  1. Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO, 63110, USA

    Min Wang, Manabu Futamura, Yian Wang & Ming You

Authors
  1. Min Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Manabu Futamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yian Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ming You
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ming You.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, M., Futamura, M., Wang, Y. et al. Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. Oncogene 24, 1958–1963 (2005). https://doi.org/10.1038/sj.onc.1208295

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1208295

Keywords

This article is cited by

Search

Advanced search

Quick links