Abstract
Deregulated centrosome duplication or maturation often results in increased centrosome size and/or centrosome number, both of which show a positive and significant correlation with aneuploidy and chromosomal instability, thus contributing to cancer formation. Given the role of Polo-like kinases (Plks) in the centrosome cycle, it is not unexpected that deregulated expression of Plks is detected in many types of cancer and is associated with oncogenesis. Extensive studies have shown that Plk1 expression is elevated in non-small-cell lung cancer, head and neck cancer, esophageal cancer, gastric cancer, melanomas, breast cancer, ovarian cancer, endometrial cancer, colorectal cancer, gliomas, and thyroid cancer. Plk1 gene and protein expression has been proposed as a new prognostic marker for many types of malignancies, and Plk1 is a potential target for cancer therapy. In contrast to Plk1, several studies have observed that Plk3 expression is negatively correlated with the development of certain cancers.
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References
Chase D, Feng Y, Hanshew B, Winkles JA, Longo DL and Ferris DK . (1998). Biochem. J., 333, 655–660.
Chen MS, Hurov J, White LS, Woodford-Thomas T and Piwnica-Worms H . (2001). Mol. Cell. Biol., 21, 3853–3861.
Cogswell JP, Brown CE, Bisi JE and Neill SD . (2000). Cell Growth Differ., 11, 615–623.
Conn CW, Hennigan RF, Dai W, Sanchez Y and Stambrook PJ . (2000). Cancer Res., 60, 6826–6831.
Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A and Bejarano P . (2000). Genes Chromosomes Cancer, 27, 332–336.
Dai W, Liu T, Wang Q, Rao CV and Reddy BS . (2002). Int. J. Oncol., 20, 121–126.
Descombes P and Nigg EA . (1998). EMBO J., 17, 1328–1335.
Dietzmann K, Kirches E, von Bossanyi P, Jachau K and Mawrin C . (2001). J. Neurooncol., 53, 1–11.
Donohue PJ, Alberts GF, Guo Y and Winkles JA . (1995). J. Biol. Chem., 270, 10351–10357.
Elez R, Piiper A, Giannini CD, Brendel M and Zeuzem S . (2000). Biochem. Biophys. Res. Commun., 269, 352–356.
Fenton B and Glover DM . (1993). Nature, 363, 637–640.
Fisher RAH and Ferris DK . (2002). Curr. Med. Chem. Imun. Endoc. Metab. Agents, 2, 1–10.
Glover DM, Hagan IM and Tavares AA . (1998). Genes Dev., 12, 3777–3787.
Glover DM, Ohkura H and Tavares A . (1996). J. Cell Biol., 135, 1681–1684.
Hamanaka R, Maloid S, Smith MR, O’Connell CD, Longo DL and Ferris DK . (1994). Cell Growth Differ., 5, 249–257.
Hamanaka R, Smith MR, O’Connor PM, Maloid S, Mihalic K, Spivak JL, Longo DL and Ferris DK . (1995). J. Biol. Chem., 270, 21086–21091.
Ito Y, Miyoshi E, Sasaki N, Kakudo K, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Matsuura N, Kuma K and Miyauchi A . (2004). Br. J. Cancer, 90, 414–418.
Knecht R, Elez R, Oechler M, Solbach C, von Ilberg C and Strebhardt K . (1999). Cancer Res., 59, 2794–2797.
Knecht R, Oberhauser C and Strebhardt K . (2000). Int. J. Cancer, 89, 535–536.
Kneisel L, Strebhardt K, Bernd A, Wolter M, Binder A and Kaufmann RJ . (2002). Cutan. Pathol., 29, 354–358.
Kotani S, Tugendreich S, Fujii M, Jorgensen P, Watanabe N, Hoog C, Hieter P and Todokoro K . (1998). Mol. Cell, 1, 371–380.
Kumagai A and Dunphy WG . (1996). Science, 273, 1377–1380.
Lane HA and Nigg EA . (1996). J. Cell Biol., 135, 1701–1713.
Lee KS and Erikson RL . (1997). Mol. Cell. Biol., 17, 3408–3417.
Lee KS, Grenfell TZ, Yarm FR and Erikson RL . (1998). Proc. Natl. Acad. Sci. USA, 95, 9301–9306.
Lee KS, Song S and Erikson RL . (1999). Proc. Natl. Acad. Sci. USA, 96, 14360–14365.
Lee M, Daniels MJ and Venkitaraman AR . (2004). Oncogene, 23, 865–872.
Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L and Dai W . (1996). J. Biol. Chem., 271, 19402–19408.
Liu X and Erikson RL . (2002). Proc. Natl. Acad. Sci. USA, 99, 8672–8676.
Liu X and Erikson RL . (2003). Proc. Natl. Acad. Sci. USA, 100, 5789–5794.
Llamazares S, Moreira A, Tavares A, Girdham C, Spruce BA, Gonzalez C, Karess RE, Glover DM and Sunkel CE . (1991). Genes Dev., 5, 2153–2165.
Macmillan JC, Hudson JW, Bull S, Dennis JW and Swallow CJ . (2001). Ann. Surg. Oncol., 8, 729–740.
Masuda Y, Nishida A, Hori K, Hirabayashi T, Kajimoto S, Nakajo S, Kondo T, Asaka M and Nakaya K . (2003). Oncogene, 22, 1012–1023.
Mundt KE, Golsteyn R, Lane HA and Nigg EA . (1997). Biochem. Biophys. Res. Commun., 239, 377–385.
Nigg EA . (1998). Curr. Opin. Cell Biol., 10, 776–783.
Nigg EA . (2001). Nat. Rev. Mol. Cell. Biol., 2, 21–32.
Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B and Dai W . (1997). J. Biol. Chem., 272, 28646–28651.
Shimizu S and Osada H . (2000). Nat. Cell Biol., 2, 852–854.
Smith MR, Wilson ML, Hamanaka R, Chase D, Kung H, Longo DL and Ferris DK . (1997). Biochem. Biophys. Res. Commun., 234, 397–405.
Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA and Medema RH . (2000). Nat. Cell Biol., 2, 672–676.
Spankuch-Schmitt B, Bereiter-Hahn J, Kaufmann M and Strebhardt K . (2002). J. Natl. Cancer Inst., 94, 1863–1877.
Stevenson CS . (1999). Proceeding of 90th American Association for Cancer Research, Washington DC.
Strebhardt K, Kneisel L, Linhart C, Bernd A and Kaufmann R . (2000). JAMA, 283, 479–480.
Takahashi T, Sano B, Nagata T, Kato H, Sugiyama Y, Kunieda K, Kimura M, Okano Y and Saji S . (2003). Cancer Sci., 94, 148–152.
Takai N, Miyazaki T, Fujisawa K, Nasu K, Hamanaka R and Miyakawa I . (2001a). Cancer Lett., 164, 41–49.
Takai N, Miyazaki T, Fujisawa K, Nasu K, Hamanaka R and Miyakawa I . (2001b). Cancer Lett., 169, 41–49.
Takai N, Miyazaki T, Miyakawa I and Hamanaka R . (2000). Reprod. Fertil. Dev., 12, 59–67.
Takai N, Yoshimatsu J, Nishida Y, Narahara H, Miyakawa I and Hamanaka R . (1999). Reprod. Fertil. Dev., 11, 31–35.
Tokumitsu Y, Mori M, Tanaka S, Akazawa K, Nakano S and Niho Y . (1999). Int. J. Oncol., 15, 687–692.
vanVugt MA, Smits VA, Klompmaker R and Medema RH . (2001). J. Biol. Chem., 276, 41656–41660.
Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M and Dai W . (2002). Mol. Cell. Biol., 22, 3450–3459.
Weichert W, Denkert C, Schmidt M, Gekeler V, Wolf G, Kobel M, Dietel M and Hauptmann S . (2004). Br. J. Cancer, 90, 815–821.
Wiest J, Clark AM and Dai W . (2001). Genes Chromosomes Cancer, 32, 384–389.
Wolf G, Elez R, Doermer A, Holtrich U, Ackermann H, Stutte HJ, Altmannsberger HM, Rubsamen-Waigmann H and Strebhardt K . (1997). Oncogene, 14, 543–549.
Wolf G, Hidenbrand R, Schwar C, Grobholz R, Kaufmann M, Stutte HJ, Strebhardt K and Bleyl U . (2000). Pathol. Res. Pract., 196, 753–759.
Yoshimatsu J, Takai N, Yoshimatsu Y, Narahara H, Miyakawa I and Hamanaka R . (1999). Res. Commun. Mol. Pathol. Pharmacol., 106, 3–12.
Yuan J, Horlin A, Hock B, Stutte HJ, Rubsamen-Waigmann H and Strebhardt K . (1997). Am. J. Pathol., 150, 1165–1172.
Yuan J, Kramer A, Eckerdt F, Kaufmann M and Strebhardt K . (2002). Cancer Res., 62, 4186–4190.
Acknowledgements
We thank Dr Douglas K Ferris (National Cancer Institute, Frederick, MD) for critical evaluation of the manuscript. This publication has been supported by a Grant-in-Aid (No. 16790961) for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
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Takai, N., Hamanaka, R., Yoshimatsu, J. et al. Polo-like kinases (Plks) and cancer. Oncogene 24, 287–291 (2005). https://doi.org/10.1038/sj.onc.1208272
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DOI: https://doi.org/10.1038/sj.onc.1208272
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