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The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis

Oncogene volume 23, pages 8432–8438 (2004)Cite this article

Abstract

We recently isolated the r-PTPeta gene, which encodes a receptor-type tyrosine phosphatase protein that suppresses the neoplastic phenotype of retrovirally transformed rat thyroid cells. The human homologue gene PTPRJ/DEP-1 is deleted in various tumors. Moreover, the Gln276Pro polymorphism, located in the extracellular region of the gene, seems to play a critical role in susceptibility to some human neoplasias. Here we report the loss of heterozygosity (LOH) of PTPRJ in 11/76 (14.5%) informative thyroid tumors (including adenomas and carcinomas). We also looked for the Gln276Pro, Arg326Gln and Asp872Glu polymorphisms in exons 5, 6 and 13 of PTPRJ in 88 patients with thyroid tumors and in 54 healthy individuals. We found that the PTPRJ genotypes homozygous for the Gln276Pro and Arg326Gln polymorphisms, and the Asp872 allele were more frequent in thyroid carcinoma patients than in healthy individuals (P=0.032). In addition, PTPRJ LOH was more frequent in thyroid carcinomas of heterozygotes for Gln276Pro and Arg326Gln compared with homozygotes (P=0.006). This suggests that the presence of hemizygosity for these polymorphisms in the tumor facilitates tumor progression. These results indicate that the genotypic profile of PTPRJ affects susceptibility to thyroid carcinomas, and that allelic loss of this gene is involved in thyroid carcinogenesis.

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Acknowledgements

We acknowledge Dr Peter Demant for helpful comments and suggestions. We are indebted to Jean Ann Gilder for editing the text. This work was supported by grants from the Associazione Italiana Ricerca sul Cancro (AIRC), the Consiglio Nazionale delle Ricerche, the Ministero dell'Università e della Ricerca Scientifica e Tecnologica (MIUR), and ‘Piani di Potenziamento della Rete Scientifica e Tecnologica’ CLUSTER C-04, and the ‘Ministero della Salute’. We thank the Associazione Partenopea per le Ricerche Oncologiche (APRO) for its support. I.L.P. is supported by an AIRC fellowship.

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Authors and Affiliations

  1. Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia di Catanzaro, Università degli Studi di Catanzaro ‘Magna Graecia’, Catanzaro, 88100, Italy

    Rodolfo Iuliano, Ilaria Le Pera, Carmela Cristofaro, Francesco Baudi, Franco Arturi, Maria Luisa Martelli, Francesco Trapasso, Lorenzo Chiariotti & Alfredo Fusco

  2. Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R. c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università di Napoli ‘Federico II’, Napoli, 80131, Italy

    PierLorenzo Pallante & Alfredo Fusco

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  1. Rodolfo Iuliano
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  2. Ilaria Le Pera
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  3. Carmela Cristofaro
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  7. Maria Luisa Martelli
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  8. Francesco Trapasso
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  9. Lorenzo Chiariotti
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  10. Alfredo Fusco
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Correspondence to Alfredo Fusco.

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Iuliano, R., Pera, I., Cristofaro, C. et al. The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis. Oncogene 23, 8432–8438 (2004). https://doi.org/10.1038/sj.onc.1207766

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  • DOI: https://doi.org/10.1038/sj.onc.1207766

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