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SUMO: a regulator of gene expression and genome integrity

Oncogene volume 23, pages 1998–2008 (2004)Cite this article

Abstract

Post-translational modification with the ubiquitin-like SUMO protein is involved in the regulation of many cellular key processes. The SUMO system modulates signal transduction pathways, including cytokine, Wnt, growth factor and steroid hormone signalling. SUMO frequently restrains the activity of downstream transcription factors in these pathways presumably by facilitating the recruitment of corepressors or mediating the assembly of repressor complexes. Additionally, evidence is accumulating that SUMO controls pathways important for the surveillance of genome integrity. SUMO regulates the PML/p53 tumour suppressor network, a key determinant in the cellular response to DNA damage. Moreover, proteins that maintain genomic stability by functioning at the interface between DNA replication, recombination and repair processes undergo SUMOylation. We will discuss some key findings that exemplify the role of SUMO in transcriptional regulation and genome surveillance.

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Acknowledgements

We thank Stefan Jentsch, Alexander Buchberger and Olaf Stemmann for helpful discussions. Our work was supported by the German-Israeli Foundation for Scientific Research and Development and the Deutsche Forschungsgemeinschaft.

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  1. Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, D-82152, Germany

    Stefan Müller, Andreas Ledl & Darja Schmidt

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Correspondence to Stefan Müller.

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Müller, S., Ledl, A. & Schmidt, D. SUMO: a regulator of gene expression and genome integrity. Oncogene 23, 1998–2008 (2004). https://doi.org/10.1038/sj.onc.1207415

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