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Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels

Oncogene volume 22, pages 6557–6563 (2003)Cite this article

Abstract

Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory component of the transforming growth factor -β receptor complex and is involved in vascular development and remodelling. Quantification of intratumoral microvessel density by CD105 staining and of circulating soluble CD105 has been suggested to have prognostic significance in selected neoplasias. In addition, the potential usefulness of CD105 in tumor imaging and antiangiogenetic therapy has been well documented utilizing different animal models.

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Acknowledgements

This work was supported in part by the Associazione Italiana per la Ricerca sul Cancro and by the progetto Ricerca Finalizzata awarded by the Italian Ministry of Public Health.

We acknowledge Dr Anna D'Amato for her skillful editorial assistance.

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Authors and Affiliations

  1. Department of Medical Oncology, Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientific, Aviano, 33081, Italy

    Ester Fonsatti, Maresa Altomonte & Michele Maio

  2. Istituto di Biologia e Patologia Molecolare, Consiglio Nazionale delle Ricerche, Rome, 00156, Italy

    Maria Rita Nicotra

  3. Laboratory of Immunology, Centro Ricerca Sperimentale Istituto Regina Elena, Rome, 00158, Italy

    Pier Giorgio Natali

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  1. Ester Fonsatti
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Correspondence to Michele Maio.

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Fonsatti, E., Altomonte, M., Nicotra, M. et al. Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels. Oncogene 22, 6557–6563 (2003). https://doi.org/10.1038/sj.onc.1206813

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