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  • Oncogenomics
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Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34

Oncogene volume 23, pages 1014–1020 (2004)Cite this article

Abstract

Meningioma is a frequently occurring tumor of the meninges surrounding the central nervous system. Loss of the short arm of chromosome 1 (1p) is the second most frequent chromosomal abnormality observed in these tumors. Previously, we identified a 3.7 megabase (Mb) region of consistent deletion on 1p33–p34 in a panel of 157 tumors. Loss of this region was associated with advanced disease and predictive for tumor relapse. In this report, a high-resolution integrated map of the region was constructed (CompView) to identify all markers in the smallest region of overlapping deletion (SRO). A regional somatic cell hybrid panel was used to more precisely localize those markers identified in CompView as within or overlapping the region. Additional deletion mapping using microsatellites localized to the region narrowed the SRO to approximately 2.8 Mb. The 88 markers remaining in the SRO were used to screen genomic databases to identify large-insert clones. Clones were assembled into a physical map of the region by PCR-based, sequence-tagged site (STS) content mapping. A sequence from clones was used to validate STS content by electronic PCR and to identify transcripts. A minimal tiling path of 43 clones was constructed across the SRO. Sequence data from the most current sequence assembly were used for further validation. A total of 59 genes were ordered within the SRO. In all, 17 of these were selected as likely candidates based on annotation using Gene Ontology Consortium terms, including the MUTYH, PRDX1, FOXD2, FOXE3, PTCH2, and RAD54L genes. This annotation of a putative tumor suppressor locus provides a resource for further analysis of meningioma candidate genes.

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Acknowledgements

This work was supported by grants from the National Cancer Center (EPS), the National Institutes of Health CA-39771 (GMB) and MH-60240 (PSW), and the Audrey E. Evans Endowed Chair (GMB). We also thank Dr John Maris and Dr Michael Hogarty for their helpful advice, Dr Jan Dumanski for providing meningioma specimens, Dr John Cowell for the somatic cell hybrid DNAs, and Tamar Marensky and Bing Kung for their technical assistance.

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  1. The Fels Institute for Molecular Biology and Cancer Research, Temple University School of Medicine, Philadelphia, 19140, PA, USA

    Erik P Sulman

  2. Division of Oncology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA

    Erik P Sulman, Peter S White & Garrett M Brodeur

  3. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA

    Peter S White & Garrett M Brodeur

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  1. Erik P Sulman
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Correspondence to Garrett M Brodeur.

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Sulman, E., White, P. & Brodeur, G. Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34. Oncogene 23, 1014–1020 (2004). https://doi.org/10.1038/sj.onc.1206623

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