Abstract
Human lymphomas continue to represent a major challenge in oncology, and in particular occur at very high frequencies in AIDS patients. We report here the development of a CD30+ lymphoproliferative disease in mice lacking the proapoptotic transcription factor, interferon regulatory factor-1. These mice most closely represent a model of human anaplastic large-cell lymphoma (ALCL). This mouse model of lymphoma will likely be useful in understanding the development of ALCL and in understanding the development of other closely related CD30+ forms of lymphoma, such as CD30+ Hodgkin's disease and CD30+ cutaneous T-cell lymphoma. This mouse model will also be useful in testing therapies for different forms of CD30+ lymphoma, in particular anti-CD30-based therapies.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Aizawa SF, Nakano HF, Ishida TF, Horie RF, Nagai MF, Ito KF, Yagita HF, Okumura KF, Inoue JF and Watanabe T . (1997). J. Biol. Chem., 272, 2042–2045.
Amakawa R, Hakem A, Kundig TM, Matsuyama T, Simard JJ, Timms E, Wakeham A, Mittruecker HW, Griesser H, Takimoto H, Schmits R, Shahinian A, Ohashi P, Penninger JM and Mak TW . (1996). Cell, 84, 551–562.
Anagnostopoulos I, Hummel M, Kaudewitz P, Herbst H, Braun-Falco O and Stein H . (1990). Am. J. Pathol., 137, 1317–1322.
Andreesen R, Osterholz J, Lohr GW and Bross KJ . (1984). Blood, 63, 1299–1302.
Annunziata CM, Safiran YJ, Irving SG, Kasid UN and Cossman J . (2000). Blood, 96, 2841–2848.
Bai RYF, Ouyang TF, Miething CF, Morris SWF, Peschel CF and Duyster J . (2000). Blood, 96, 4319–4327.
Bartett M, Galipeau P, Sanchez C, Emond M and Reid B . (1996). Oncogene, 12, 1873–1878.
Bashir MS, Jones DB and Wright DH . (1992). Clin. Exp. Immunol., 88, 543–547.
Baur AS, Shaw P, Burri N, Delacretaz F, Bosman FT and Chaubert P . (1999). Blood, 94, 1773–1781.
Bischof DF, Pulford KF, Mason DYF and Morris SW . (1997). Mol. Cell. Biol., 17, 2312–2325.
Blanar M, Baldwin A, Flavell R and Sharpe P . (1989). EMBO J., 8, 1139–1144.
Briken V, Ruffner H, Schultz U, Schwarz A, Reis L, Strehlow I, Decker T and Staeheli P . (1995). Mol. Cell. Biol., 15, 975–982.
Carbone A, Tirelli U, Vaccher E, Volpe R, Gloghini A, Bertola G, De R, Rossi VC, Boiocchi M and Monfardini S . (1991). Cancer, 68, 842–852.
Chadburn A, Cesarman E, Jagirdar J, Subar M, Mir RN and Knowles DM . (1993). Cancer, 72, 3078–3090.
Chan WC . (2001). Hematol. Oncol., 19, 1–17.
Chang C, Hammer J, Loh J, Fodor W and Flavell R . (1992). Immunogenetics, 35, 378–384.
Del Prete G, De Carli M, Almerigogna F, Daniel CK, D’Elios MM, Zancuoghi G, Vinante F, Pizzolo G and Romagnani S . (1995a). FASEB J., 9, 81–86.
Del Prete G, Maggi E, Pizzolo G and Romagnani S . (1995b). Immunol. Today, 16, 76–80.
Duckett CS and Thompson CB . (1997). Genes Dev., 11, 2810–2821.
Duncan GS, Mittrucker HW, Kagi D, Matsuyama T and Mak TW . (1996). J. Exp. Med., 184, 2043–2048.
Eason DD and Blanck G . (2001). J. Immunol., 166, 1041–1048.
Falini B . (2001). Br. J. Haematol., 114, 741–760.
Foss HD, Anagnostopoulos I, Araujo I, Assaf C, Demel G, Kummer JA, Hummel M and Stein H . (1996). Blood, 88, 4005–4011.
Fujita T, Sakakibara J, Sudo Y, Miyamoto M, Kimura Y and Taniguchi T . (1988). EMBO J., 7, 3397–3405.
Galon J, Sudarshan C, Ito S, Finbloom D and O’Shea JJ . (1999). J. Immunol., 162, 7256–7262.
Gardner LJ, Polski JM, Evans HL, Perkins SL and Dunphy CH . (2001). Arch. Pathol. Lab. Med., 125, 1036–1041.
Gonzalez-Clemente JM, Ribera JM, Campo E, Bosch X, Montserrat E and Grau JM . (1991). AIDS, 5, 751–755.
Gruss HJ, Boiani N, Williams DE, Armitage RJ, Smith CA and Goodwin RG . (1994). Blood, 83, 2045–2056.
Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara M and Taniguchi T . (1993). Science, 259, 971–974.
Harada H, Kondo T, Ogawa S, Tamura T, Kitagawa M, Tanaka N, Lamphier MS, Hirai H and Taniguchi T . (1994). Oncogene, 9, 3313–3320.
Heinrich P, Behrmann I, Muller-Newen G, Schaper F and Graave L . (1998). Biochem. J., 334, 297–314.
Herbst H, Tippelmann G, Anagnostopoulos I, Gerdes J, Schwarting R, Boehm T, Pileri S, Jones DB and Stein H . (1989). Leuk. Res., 13, 103–116.
Heyman M, Nordgren A, Jeddi-Tehrani M, Rasool O, Liu Y, Grander D, Ost A, Wallberg B and Johansson B . (1996). Leukemia, 10, 909–917.
Hobart M, Ramassar V, Goes N, Urmson J and Halloran PF . (1997). J. Immunol., 158, 4260–4269.
Horie R, Watanabe T, Morishita Y, Ito K, Ishida T, Kanegae Y, Saito I, Higashihara M, Mori S and Kadin ME . (2002). Oncogene, 21, 2493–2503.
Hsu PL and Hsu SM . (1990). Cancer Res., 50, 350–357.
Hsu PLF and Hsu SM . (2000). Lab. Invest., 80, 1111–1119.
Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA and Weingerg RA . (1992). Nature, 359, 295–300.
Kondo T, Minamino N, Nagamura-Inoue T, Matsumoto M, Taniguchi T and Tanaka N . (1997). Oncogene, 15, 1275–1281.
Kumanishi T, Zhang S, Ichikawa T, Endo S and Washiyama K . (1996). Jpn. J. Cancer Res., 87, 691–695.
Lee EY, Chang CY, Hu N, Wang YCJ, Lai CC, Herrup K, Lee WH and Bradley A . (1992). Nature, 359, 288–294.
Lee SY and Choi Y . (1997). J. Exp. Med., 185, 1275–1285.
Marafioti T, Hummel M, Foss HD, Laumen H, Korbjuhn P, Anagnostopoulos I, Lammert H, Demel G, Theil J, Wirth T and Stein H . (2000). Blood, 95, 1443–1450.
Martin E, Nathan C and Xie Q . (1994). J. Exp. Med., 180, 977–984.
Matsuyama T, Kimura T, Kitagawa M, Pfeffer K, Kawakami T, Watanabe N, Kundig TM, Amakawa R, Kishihara K and Wakeham A . (1993). Cell, 75, 83–97.
McElligott DL, Phillips JA, Stillman CA, Koch RJ, Mosier DE and Hobbs MV . (1997). J. Immunol., 159, 4180–4186.
Mir SS, Richter BW and Duckett CS . (2000). Blood, 96, 4307–4312.
Miura I, Graziano S, Cheng J, Doyle L and Testa J . (1992). Cancer Res., 52, 1322–1328.
Miyamoto M, Fujita T, Kimura Y, Maruyama M, Harada H, Sudo Y, Miyata T and Taniguchi T . (1988). Cell, 54, 903–913.
Moller MB, Kania PW, Ino Y, Gerdes AM, Nielsen O, Louis DN, Skjodt K and Pedersen NT . (2000). Leukemia, 14, 898–904.
Nikitin AY, Juarez-Perez MI, Li S, Huang L and Lee WH . (1999). Proc. Natl. Acad. Sci. USA, 96, 3916–3921.
Nosari A, Cantoni S, Oreste P, Schiantarelli C, Landonio G, Alexiadis S, Gargantini L, Caggese L, Gambacorta M and Morra E . (1996). Br. J. Haematol., 95, 508–512.
Nozawa H, Oda E, Ishihara M, Ueda S, Yokochi T, Ogasawara K, Shimizu S, Ohira Y, Hioki K, Aizawa S, Ishikawa T, Katsuki M, Muto T, Taniguchi T and Tanaka N . (1999). Genes Dev., 13, 1240–1245.
Ogasawara K, Hida S, Azimi N, Tagaya Y, Sato T, Yokochi-Fukuda T, Waldmann TA, Taniguchi T and Taki S . (1998). Nature, 391, 700–703.
Ogasawara S, Tamura G, Maesawa C, Suzuki Y, Ishida K, Satoh N, Uesugi N, Saito K and satodate R . (1996). Gastroenterologia, 110, 52–57.
Ogawa S, Hangaishi A, Miyawaki S, Hirosawa S, Miura Y, Takeyama K, Kamada N, Ohtake S, Uike N and Shimazaki C . (1995). Blood, 86, 1548–1556.
Ohmori Y and Hamilton TA . (1995). J. Immunol., 154, 5235–5244.
Ohteki T, Yoshida H, Matsuyama T, Duncan GS, Mak TW and Ohashi PS . (1998). J. Exp. Med., 187, 967–972.
Penninger JM, Sirard C, Mittrucker HW, Chidgey A, Kozieradzki I, Nghiem M, Hakem A, Kimura T, Timms E, Boyd R, Taniguchi T, Matsuyama T and Mak TW . (1997). Immunity, 7, 243–254.
Pinyol M, Hernandez L, Cazorla M, Balbin M, Jares P, Fernandez PL, Montserrat E, Cardesa A, Lopez-Otin C and Campo E . (1997). Blood, 89, 272–280.
Ransom D, Leonard J, Kearsley J, Turbett G, Heel K, Sosars V, Hayward N and Bishop J . (1996). Head Neck, 18, 248–253.
Salkowski CA, Barber SA, Detore GR and Vogel SN . (1996). J. Immunol., 156, 3107–3110.
Siebert R, Willers CP, Schramm A, Fossa A, Dresen IM, Uppenkamp M, Nowrousian MR, Seeber S and Opalka B . (1995). Br. J. Haematol., 91, 350–354.
Smith CA, Gruss HJ, Davis T, Anderson D, Farrah T, Baker E, Sutherland GR, Brannan CI, Copeland NG and Jenkins NA . (1993). Cell, 73, 1349–1360.
Spink J and Evans T . (1997). J. Biol. Chem., 272, 24417–24425.
Sugimura J, Tamura G, Suzuki Y and Fujioka T . (1997). Pathol. Int., 47, 79–83.
Taki S, Sato T, Ogasawara K, Fukuda T, Sato M, Hida S, Suzuki G, Mitsuyama M, Shin EH, Kojima S, Taniguchi T and Asano Y . (1997). Immunity, 6, 673–679.
Tanaka N, Ishihara M, Kitagawa M, Harada H, Kimura T, Matsuyama T, Lamphier MS, Aizawa S, Mak TW and Taniguchi T . (1994). Cell, 77, 829–839.
Tanaka N, Ishihara M, Lamphier M, Nozawa H, Matsuyama T, Mak T, Aizawa S, Tokino T, Oren M and Taniguchi T . (1996). Nature, 382, 816–818.
Telford WG, Nam SY, Podack ER and Miller RA . (1997). Cell Immunol., 182, 125–136.
Uchida T, Kinoshita T, Murate T, Saito H and Hotta T . (1998). Leuk. Lymphoma, 29, 27–35.
Uchida T, Watanabe T, Kinoshita T, Murate T, Saito H and Hotta T . (1995). Blood, 86, 2724–2731.
Udayachander M, Meenakshi A, Ansamma J and Muthiah R . (1983). Br. J. Cancer, 48, 717–725.
Wendtner CM, Schmitt B, Gruss HJ, Druker BJ, Emmerich B, Goodwin RG and Hallek M . (1995). Cancer Res., 55, 4157–4161.
Widgren S . (1985). Pathol. Res. Pract., 180, 563–568.
Willman C, Sever C, Pallavicini M, Harada H, Tanaka N, Slovak M, Yamamoto H, Harada K, Meeker T, List A and Taniguchi T . (1993). Science, 259, 968–971.
Zhao N, Stoffel A, Wang P, Eisenbart D, Espinosa R, Larson R and LeBeau M . (1997). Proc. Natl. Acad. Sci., 94, 6948–6953.
Acknowledgements
This work was supported by grants to George Blanck from the National Institutes of Health (R01-CA81497) and the American Cancer Society (RPG-98-184-01-CIM). We thank Edward M Haller for expert technical assistance with the electron microscopy analyses; Jodi Kroeger and Johana Melendez for expert technical assistance at the Moffitt Flow Cytometry core facility; and Kimberly M Palubin for help with mouse genotyping.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Eason, D., LeBron, C., Coppola, D. et al. Development of CD30+ lymphoproliferative disease in mice lacking interferon regulatory factor-1. Oncogene 22, 6166–6176 (2003). https://doi.org/10.1038/sj.onc.1206563
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1206563