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Association of Vimentin overexpression and hepatocellular carcinoma metastasis

Oncogene volume 23, pages 298–302 (2004)Cite this article

Abstract

The poor prognosis of hepatocellular carcinoma (HCC) has been associated with recurrence and metastasis. Recently, we established a pair of HCC cell lines from a primary (H2-P) and its matched metastatic (H2-M) HCC tumors. A high density of cDNA microarray with 9184 human cDNA was used to identify the differentially expressed genes between H2-P and H2-M. Comparing with H2-P, eight upregulated and six downregulated genes were detected in H2-M. One interesting finding is the overexpression of Vimentin (VIM), a well-defined intermediate filament, which has been linked to a more aggressive status in various tumors. The correlation of overexpression of VIM and HCC metastasis was studied by immunohistochemistry using a tissue microarray with 200 primary HCCs and 60 pairs of primary and matched metastatic HCC samples. Tissue microarray demonstrated that the overexpression of VIM was significantly associated with HCC metastasis (P<0.01). This finding strongly suggests that the overexpression of VIM may play an important role in the metastasis of HCC.

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Acknowledgements

This work was supported by a Research Grant Council Grant HKU7236/00M and Leung Kwok Tze Foundation.

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  1. Liang Hu and Sze Hang Lau: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China

    Liang Hu, Sze Hang Lau, Dan Xie, Jonathan S T Sham & Xin-Yuan Guan

  2. Department of Biology and Chemistry, The City University of Hong Kong, Hong Kong, China

    Chi-Hung Tzang, Minghui Huang & Mengsu Yang

  3. Department of Pathology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Jian-Ming Wen, Dan Xie & Wei-Fen Zeng

  4. Department of Hepatobilliary Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Weisheng Wang & Jie-Fu Huang

  5. Eastern Hepatobilliary Surgery Hospital, The Second Military Medical University, Shanghai, China

    Yi Wang & Meng-Chao Wu

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  1. Liang Hu
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Correspondence to Xin-Yuan Guan.

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Hu, L., Lau, S., Tzang, CH. et al. Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene 23, 298–302 (2004). https://doi.org/10.1038/sj.onc.1206483

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