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TMEFF1 and brain tumors

Oncogene volume 22, pages 2723–2727 (2003)Cite this article

Abstract

TMEFF1 is a novel transmembrane protein, containing two follisatin domains and an epidermal growth factor-like region. These structural domains suggest a role for TMEFF1 in growth factor signaling. TMEFF1 fused to enhanced green fluorescent protein revealed that TMEFF1 is expressed on the cell membrane. Northern analysis of normal human tissue showed that TMEFF1 is predominantly expressed in the brain. Study of cancer cell lines from different tissues including the brain, demonstrated moderate to low levels of TMEFF1 in most of these transformed cell lines. Furthermore, quantitative real-time RT–PCR analysis of 54 brain tumors showed that most of these tumors (96%) had lower levels of TMEFF1 expression than normal brain tissue. Interestingly, ectopic expression of TMEFF1 in brain cancer cells resulted in their growth inhibition. These data suggest that TMEFF1 may behave as a tumor suppressor gene in brain cancers.

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Acknowledgements

The project was sponsored by the Department of the Army, award number DAMD17-02-1-0031. The US Army Medical Research Acquisition Activity, 820 Chandler St, Fort Detrick, MD 21702-5014 is the awarding and administering acquistion office. The content of the information does not necessarily reflect the position or policy of the government, and no official endorsement should be inferred. This work was supported in part by C and H Koeffler Research Fund. Horn Foundation and Parker Hughes Trust and a grant from the Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center. HPK is a member of the Jonsson Comprehensive Cancer Center and holds the endowed Mark Goodson Chair of Oncology Research at Cedars-Sinai Medical Center/UCLA School of Medicine.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA

    Sigal Gery, Dong Yin, Dong Xie & H Phillip Koeffler

  2. Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, CA, USA

    Keith L Black

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  1. Sigal Gery
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  2. Dong Yin
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Correspondence to Sigal Gery.

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Gery, S., Yin, D., Xie, D. et al. TMEFF1 and brain tumors. Oncogene 22, 2723–2727 (2003). https://doi.org/10.1038/sj.onc.1206351

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