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A new locus for resistance to γ-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice

Oncogene volume 21, pages 6680–6683 (2002)Cite this article

Abstract

Mice of the C57BL/6J inbred strain develop thymic lymphomas at very high frequency after acute γ-irradiation, while mice of several inbred strains derived from the wild progenitor of the Mus spretus species and their F1 hybrids with C57BL/6J appear extremely resistant. Analysis of the genetic determinism of the γ-radiation-induced thymic lymphoma (RITL) resistance with the help of inter-specific consomic strains (ICS), which carry a single introgressed Mus spretus chromosome on a C57BL/6J genetic background, provide significant evidence for the existence of a thymic lymphoma resistance (Tlyr1) locus on chromosome 19. The subsequent analysis of the backcross progeny resulting from a cross between consomic mice heterozygous for the Mus spretus chromosome 19 and C57BL/6J mice, together with the study of inter-specific recombinant congenic strains (IRCS), suggest that this Tlyr1 locus maps within the D19Mit60–D19Mit40 chromosome interval. In addition to the discovery of a new locus controlling RITL development, our study emphasizes the value of ICS and IRCS for the genetic analysis of cancer predisposition.

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Acknowledgements

We thank Javier Palacín and Fátima Plasencia for their technical help. This work was supported by grants from the European Commission within the Biomedicine and Health programme (no BMH4-98-3426) to J Santos, J-L Guénet and E Salido, the Ministerio de Ciencia y Tecnología from Spain (no PM99-0003) and Comunidad de Madrid (no 08.1/0013.1/2000) to J Fernández-Piqueras, and the Comunidad de Madrid (no 08.1/0020.2/2000) to J Santos, and by a grant from the Association pour la Recherche sur le Cancer (ARC) to J-L Guénet.

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Authors and Affiliations

  1. Departamento de Biologia, Laboratorio Genética Molecular Humana, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, 28049, Spain

    Javier Santos, Pilar López, Concepción Vaquero, Mónica Fernández & José Fernández-Piqueras

  2. Unité de Génétique des Mammifères, Institut Pasteur, Paris, 75724, France

    Xavier Montagutelli, Marek Szatanik & Jean-Louis Guénet

  3. Departamento de Anatomía Patológica, Facultad de Medicina, Universidad de La Laguna, Tenerife, 38071, Spain

    Abraham Acevedo, Maria-Rosa Arnau & Eduardo Salido

Authors
  1. Javier Santos
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  2. Xavier Montagutelli
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  3. Abraham Acevedo
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  4. Pilar López
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  5. Concepción Vaquero
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  10. Jean-Louis Guénet
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  11. José Fernández-Piqueras
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Correspondence to Javier Santos.

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Santos, J., Montagutelli, X., Acevedo, A. et al. A new locus for resistance to γ-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice. Oncogene 21, 6680–6683 (2002). https://doi.org/10.1038/sj.onc.1205846

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