Abstract
Temperature sensitive mutations in host cell factor 1 (HCF-1) arrest cells in the middle of the G1 phase of the cycle. We have shown that the highly conserved C-terminal WYF domain of HCF-1 protein interacts with the MYND domain of the PDCD2 protein. This inter‐action is conserved between human HCF-1 and HCF-2 and the C. elegansHCF. Overexpression of PDCD2, which interacts with the N-CoR/mSin3A corepressor complexes, suppresses cotransfected HCF-1 complement‐ation of a temperature lesion in the endogenous HCF-1 protein. Overexpression of domains of either PDCD2 or HCF-1, which should interfere with interactions between these two proteins, enhances the complementation.
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Scarr, R., Sharp, P. PDCD2 is a negative regulator of HCF-1 (C1). Oncogene 21, 5245–5254 (2002). https://doi.org/10.1038/sj.onc.1205647
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DOI: https://doi.org/10.1038/sj.onc.1205647
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