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Myeloid differentiation (MyD) primary response genes in hematopoiesis

Oncogene volume 21, pages 3391–3402 (2002)Cite this article

Abstract

Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45α MyD118/Gadd45β, GADD45γ, MyD116/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation. This review delineates the role MyD genes play in blood cell development, where they function as positive regulators of terminal differentiation, lineage specific blood cell development and control of blood cell homeostasis, including growth inhibition and apoptosis.

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Acknowledgements

I would like to thank Dr Arthur Balliet and Dr Arshad Amanullah for critical reading of the review. This research was supported by National Institute of Health Grants 1RO1CA43618 and 1R01CA59774 (to DA Liebermann).

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  1. Fels Institute for Cancer Research and Molecular Biology and the Department of Biochemistry, Temple University School of Medicine, Philadelphia, 19140, Pennsylvania, PA, USA

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Liebermann, D., Hoffman, B. Myeloid differentiation (MyD) primary response genes in hematopoiesis. Oncogene 21, 3391–3402 (2002). https://doi.org/10.1038/sj.onc.1205312

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