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Emc, a negative HLH regulator with multiple functions in Drosophila development

Oncogene volume 20, pages 8299–8307 (2001)Cite this article

Abstract

Expression and functional analyses of Emc have demonstrated that it is a prototype for a protein required for multiple processes in development. Initially characterized as a negative regulator of sensory organ development, it was later found to regulate many other developmental processes and cell proliferation. Its ability to block the function of bHLH proteins by forming heterodimers, which are ineffective in DNA binding, accounts for the role of Emc in preventing the acquisition of several cell fates which are under the control of bHLH proteins. However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation.

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References

  • Affolter M, Shilo BZ . 2000 Curr. Opin. Cell Biol. 12: 731–735

  • Armand P, Knapp AC, Hirsch AJ, Wieschaus EF, Cole MD . 1994 Mol. Cell. Biol. 14: 4145–4154

  • Artavanis-Tsakonas S, Rand MD, Lake RJ . 1999 Science 284: 770–776

  • Baker B . 1989 Nature 340: 521–524

  • Balcells L, Modolell J, Ruiz-Gómez M . 1988 EMBO J. 7: 3899–3906

  • Baonza A, de Celis JF, García-Bellido A . 2000 Development 127: 2383–2393

  • Baonza A, Freeman M . 2001 Development 128: 3889–3898

  • Baonza A, García-Bellido A . 1999 Mech. Dev. 80: 133–146

  • Bate M . 1978 Handbook of Sensory Physiology Vol 1X: M Jacobson (ed) New York: Springer

    Google Scholar 

  • Baumann P, Skaer H . 1993 Development Suppl 65–76

  • Baylies MK, Bate M, Ruiz-Gómez M . 1998 Cell 93: 921–927

  • Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H . 1990 Cell 61: 49–59

  • Bodmer R, Carretto R, Jan YN . 1989 Neuron 3: 21–32

  • Botas J, Moscoso del Prado J, García-Bellido A . 1982 EMBO J. 1: 307–310

  • Cabrera CV, Alonso MC, Huikeshoven H . 1994 Development, 120: 3595–3603

  • Brown NL, Sattler CA, Paddock SW, Carroll SB . 1995 Cell 80: 879–887

  • Cabrera CV, Martínez-Arias A, Bate M . 1987 Cell 50: 425–433

  • Carmena A, Bate M, Jiménez F . 1995 Genes Dev. 9: 2373–2383

  • Carrera P, Abrell S, Kerber B, Walldorf U, Preiss A, Hogh M, Jäckle H . 1998 Proc. Natl. Acad. Sci. USA 95: 10779–10784

  • Castanon I, Von Stetina S, Kass J, Baylies MK . 2001 Development 128: 3145–3159

  • Caudy M, Grell EH, Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN . 1988a Genes Dev. 2: 843–852

  • Caudy M, Vassin H, Brand M, Tuma R, Jan LY, Jan YN . 1988b Cell 55: 1061–1067

  • Chen C-M, Freedman JA, Bettler DR, Manning SD, Giep SN, Steiner J, Ellis HM . 1996 Mech. Dev. 57: 215–227

  • Cline TW . 1988 Genetics 119: 829–862

  • Cline TW . 1989 Cell 59: 231–234

  • Cline TW, Meyer BJ . 1996 Annu. Rev. Genet. 30: 637–702

  • Cubas P, Modolell J . 1992 EMBO J. 11: 3385–3393

  • Cubas P, de Celis JF, Campuzano S, Modolell J . 1991 Genes Dev. 5: 996–1008

  • Cubas P, Modolell J, Ruiz-Gómez M . 1994 Development 120: 2555–2566

  • Dambly-Chaudière C, Ghysen A, Jan LY, Jan YN . 1988 Roux's Arch. Dev. Biol. 197: 419–423

  • Davis RL, Cheng PF, Lassar AB, Weintraub H . 1990 Cell 60: 733–746

  • de Celis JF . 1998 Int. J. Dev. Biol. 42: 335–343

  • de Celis JF, García-Bellido A . 1994 Mech. Dev. 46: 109–122

  • de Celis JF, Baonza A, García-Bellido A . 1995 Mech. Dev. 53: 209–221

  • Dimitratos SD, Woods DF, Stathakis DG, Bryant PJ . 1999 BioEssays 21: 912–921

  • Dokucu ME, Zipursky SL, Cagan RL . 1996 Development 122: 4139–4147

  • Ellis HM . 1994 Mech. Dev. 47: 65–72

  • Ellis HM, Spann DR, Posakony JW . 1990 Cell 61: 27–38

  • Erickson JW, Cline TW . 1991 Science 251: 1071–1074

  • Erickson JW, Cline TW . 1993 Genes Dev. 9: 1688–1702

  • Freeman M . 1997 Development 124: 261–270

  • García-Bellido A . 1979 Genetics 91: 491–520

  • García-Alonso LA, García-Bellido A . 1988 Roux's Arch. Dev. Biol. 197: 328–338

  • García-Bellido A, Merriam J . 1971 Develop. Biol. 24: 61–87

  • García-Bellido A, Santamaría P . 1978 Genetics 88: 469–486

  • Garrell J, Campuzano S . 1991 BioEssays 13: 493–498

  • Garrell J, Modolell J . 1990 Cell 61: 39–48

  • Ghysen A, Dambly-Chaudière C . 1989 Trends Genet. 5: 251–255

  • Gómez-Skarmeta JL, Rodríguez I, Martínez C, Culí J, Ferrés-Marcó MD, Beamonte D, Modolell J . 1995 Genes Dev. 9: 1869–1882

  • Hartenstein V, Posakony JW . 1989 Development 107: 389–405

  • Hoch M, Broadie K, Jäckle H, Skaer H . 1994 Development 120: 3439–3450

  • Jan YN, Jan LY . 1993 Cell 75: 827–830

  • Jarman AP, Grell EH, Ackerman L, Jan LY, Jan YN . 1994 Nature 369: 398–400

  • Kageyama R, Nakanishi S . 1997 Curr. Opin. Genet. Dev. 7: 659–665

  • King PH, Levine TD, Fremeau Jr RT, Keene JD . 1994 J. Neurosci. 14: 1943–1952

  • Lai EC, Posakony JW . 1997 Development 124: 4847–4856

  • Lai EC, Posakony JW . 1998 Cell 93: 1103–1104

  • Lee T, Hacohen N, Krasnow M, Montell D . 1996 Genes Dev. 10: 2912–2921

  • Leviten MW, Lai EC, Posakony JW . 1997 Development 124: 4039–4051

  • Lisbin MJ, Qiu J, White K . 2001 Genes Dev. 15: 2546–2561

  • Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O'Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K, Benezra R . 1999 Nature 401: 670–677

  • Martínez C, Modolell J, Garrell J . 1993 Mol. Cell. Biol. 13: 3514–3521

  • Massari ME, Murre C . 2000 Mol. Cell. Biol. 20: 429–440

  • Modolell J, Campuzano S . 1998 Int. J. Dev. Biol. 42: 275–282

  • Moscoso del Prado J, García-Bellido A . 1984a Roux's Arch. Dev. Biol. 193: 246–251

  • Moscoso del Prado J, García-Bellido A . 1984b Roux's Arch. Dev. Biol. 193: 242–245

  • Murre C, McCaw PS, Baltimore D . 1989a Cell 56: 777–783

  • Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Baltimore D . 1989b Cell 58: 537–544

  • Norton JD . 2000 J. Cell Sci. 113: 3897–3905

  • Ohshiro T, Saigo K . 1997 Development 124: 3975–3986

  • Parkhurst SM, Bopp D, Ish-Horowicz D . 1990 Cell 63: 1179–1191

  • Ready DF, Hanson TE, Benzer S . 1976 Dev. Biol. 53: 217–240

  • Robinow S, White K . 1988 Dev. Biol. 126: 294–303

  • Rodríguez I, Hernández R, Modolell J, Ruiz-Gómez M . 1990 EMBO J. 9: 3583–3592

  • Romani S, Campuzano S, Macagno E, Modolell J . 1989 Genes Dev. 3: 997–1007

  • Skaer H . 1993 The development of Drosophile melanogaster Martínez-Arias A and Bate M (eds) Cold Spring Harbor Lab. Press: New York. Cold Spring Harbor

    Google Scholar 

  • Skeath JB, Carroll SB . 1991 Genes Dev. 5: 984–995

  • Takahisa M, Togashi S, Suzuki T, Kobayashi M, Murayama A, Kondo K, Miyake T, Ueda R . 1996 Genes Dev. 10: 1783–1795

  • Torres M, Sánchez L . 1989 EMBO J. 8: 3079–3086

  • Torres M, Sánchez L . 1991 Development 113: 715–722

  • Van Doren M, Ellis HM, Posakony JW . 1991 Development 113: 245–255

  • Van Doren M, Powell PA, Pasternak D, Singson A, Posakony JW . 1992 Genes Dev. 6: 2592–2605

  • Villares R, Cabrera CV . 1987 Cell 50: 415–424

  • Voronova A, Baltimore D . 1990 Proc. Natl. Acad. Sci. USA 87: 4722–4726

  • Wie X, Ellis HM . 2001 Mech. Dev. 100: 217–231

  • Younger-Shepherd S, Vaessin H, Bier E, Jan LY, Jan YN . 1992 Cell 70: 911–922

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Acknowledgements

I would like to thank J Modolell, M Ruiz-Gómez and J de Celis for comments on the manuscript. Support from DGICYT, Comunidad Autónoma de Madrid and an institutional grant from Fundación Ramón Areces to the Centro de Biología Molecular Severo Ochoa is acknowledged.

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  1. Centro de Biología Molecular Severo Ochoa, Cantoblanco, 28049, Madrid, Spain

    Sonsoles Campuzano

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  1. Sonsoles Campuzano
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Correspondence to Sonsoles Campuzano.

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Campuzano, S. Emc, a negative HLH regulator with multiple functions in Drosophila development. Oncogene 20, 8299–8307 (2001). https://doi.org/10.1038/sj.onc.1205162

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