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Signaling via Shc family adapter proteins

Oncogene volume 20, pages 6322–6330 (2001)Cite this article

Abstract

The adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then a number of studies in multiple systems have implicated a role for Shc in signaling via many different types of receptors, such as growth factor receptors, antigen receptors, cytokine receptors, G-protein coupled receptors, hormone receptors and integrins. In addition to the ubiquitous ShcA, two other shc gene products, ShcB and ShcC, which are predominantly expressed in neuronal cells, have also been identified. ShcA knockout mice are embryonic lethal and have clearly suggested an important role for ShcA in vivo. Based on dominant negative studies and mouse embryos deficient in ShcA, a clear role for Shc in leading to mitogen activated protein kinase (MAPK) activation has been established. However MAPK activation may not be the sole function of Shc proteins. Although Shc has also been linked to other signaling events such as c-Myc activation and cell survival, the mechanistic understanding of these signaling events remains poorly characterized. Given the apparently central role that Shc plays signaling via many receptors, delineating the precise mechanism(s) of Shc-mediated signaling may be critical to our understanding of the effects mediated through these receptors.

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Acknowledgements

I thank Hua-Poo Su, Li Zhang and other members of my laboratory for input and discussions. I apologize to many of my colleagues whose work could not be quoted due to space constraints. This work was supported by the NIH grant GM-55761.

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  1. Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, Virginia, USA

    Kodi S Ravichandran

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Ravichandran, K. Signaling via Shc family adapter proteins. Oncogene 20, 6322–6330 (2001). https://doi.org/10.1038/sj.onc.1204776

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