Abstract
Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.
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References
Arsenian S, Weinhold B, Oelgeschlager M, Ruther U, Nordheim A . 1998 EMBO J. 17: 6289–6299
Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K . 1995 Current Protocols in Molecular Biology Greene Assoc., NY
Belaguli NS, Schildmeyer LA, Schwartz RJ . 1997 J. Biol. Chem. 272: 18222–18231
Bushel P, Kim JH, Chang W, Catino JJ, Ruley HE, Kumar CC . 1995 Oncogene 10: 1361–1370
Catala F, Wanner R, Barton P, Cohen A, Wright W, Buckingham M . 1995 Mol. Cell. Biol. 15: 4585–4596
Chambon P . 1996 FASEB J. 10: 940–954
Chen JD, Evans RM . 1995 Nature 377: 454–457
Choi HS, Chung M, Tzameli I, Simha D, Lee YK, Seol W, Moore DD . 1997 J. Biol. Chem. 272: 23565–23571
Forman BM, Tzameli I, Choi HS, Chen J, Simha D, Seol W, Evans RM, Moore DD . 1998 Nature 395: 612–615
Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG . 1995 Nature 377: 397–404
Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel A, Olefsky JM . 1994 Mol. Cell. Biol. 14: 7466–7475
Johansen FF, Prywes R . 1994 Mol. Cell. Biol. 14: 5920–5928
Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, Rosenfeld MG . 1996 Cell 85: 403–414
Kim H-J, Kim JH, Lee JW . 1998 J. Biol. Chem. 273: 28564–28567
Kim JH, Johansen FE, Robertson N, Catino JJ, Prywes R, Kumar CC . 1994 J. Biol. Chem. 269: 13740–13743
Lee JW, Lee YC, Na SY, Jung DJ, Lee SK . 2001 Cell. Mol. Life Sci. 58: 289–297
Lee SK, Kim JH, Lee YC, Cheong J, Lee JW . 2000 J. Biol. Chem. 275: 12470–12474
Lee JW, Gulick T, Moore DD . 1992 Mol. Endocrinol. 6: 1867–1873
Lotan R . 1996 FASEB J. 10: 1031–1039
Poser S, Impey S, Trinh K, Xia Z, Storm DR . 2000 EMBO J. 19: 4955–4966
Ramirez S, Ait S, Ali S, Robin P, Trouche D, Harel-Bellan A . 1997 J. Biol. Chem. 272: 31016–31021
Seol W, Choi HS, Moore DD . 1996 Science 272: 1336–1339
Slack JL . 1999 Curr. Opin. Hematol. 6: 236–240
Sotiropoulos A, Gineitis D, Copeland J, Treisman R . 1999 Cell. 98: 159–169
Tagami T, Madison LD, Nagaya T, Jameson JL . 1997 Mol. Cell. Biol. 17: 2642–2648
Treisman R . 1994 Curr. Opin. Genet. Dev. 4: 96–101
Xu L, Glass CK, Rosenfeld MG . 1999 Curr. Opin. Genet. Dev. 9: 140–147
Acknowledgements
We thank Drs Larry Jameson and Richard Treisman for plasmids. This research was exclusively supported by a grant from the National Creative Research Initiatives Program of the Korean Ministry of Science and Technology.
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Kim, SW., Kim, HJ., Jung, DJ. et al. Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins. Oncogene 20, 6638–6642 (2001). https://doi.org/10.1038/sj.onc.1204695
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DOI: https://doi.org/10.1038/sj.onc.1204695