Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Report
  • Published:

Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein

Oncogene volume 19, pages 827–830 (2000)Cite this article

Abstract

We have previously demonstrated that the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein represses the trans-activation function of p53 tumor suppressor protein. Recently, several proteins with sequence homology to p53 have been identified. In this study, we demonstrated that Tax represses the trans-activation functions of p73α, p73β, and p51A, the p53-related proteins, as well as p53. Moreover, a mutant Tax of coactivator CBP-binding site (K88A), which activated NF-κB but not CREB pathway, could not repress the p73 nor p51 trans-activation functions, indicating that CBP-binding domain of Tax is essential for the suppression of their functions. Using proteins of Gal4-fused N-terminal region of p73 and p51, we showed that Tax-mediated inactivation of p73 or p51 requires for their N-terminal trans-activation domains. Furthermore, only the putative N-terminal trans-activation domains of them did not have enough transcriptional activities and their adjacent regions are essential for their full trans-activation, suggesting the existence of their second trans-activation subdomains. Thus, HTLV-1 Tax inactivated the p53-related proteins through their N-terminal trans-activation domains.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5

Similar content being viewed by others

References

  • Akagi T, Ono H, Tsuchida N and Shimotohno K. . 1997a FEBS Lett. 406: 263–266.

  • Akagi T, Ono H, Nyunoya H and Shimotohno K. . 1997b Oncogene 14: 2071–2078.

  • Bargonetti J, Reynisdottir I, Friedman P and Prives C. . 1992 Genes Dev. 6: 1886–1898.

  • Cereseto A, Diella F, Mulloy JC, Cara A, Michieli P, Grassmann R, Franchini G and Klotman ME. . 1996 Blood 88: 1551–1560.

  • Chang J, Kim D-H, Lee SW, Choi KY and Sung YC. . 1995 J. Biol. Chem. 270: 25014–25019.

    Article  CAS  Google Scholar 

  • de Laurenzi V, Costanzo A, Barcaroli D, Terrinoni A, Falco M, Annicchiarico-Petruzzelli M, Levrero M and Melino G. . 1998 J. Exp. Med. 188: 1763–1768.

  • Dobner T, Horikoshi N, Rubenwolf S and Shenk T. . 1996 Science 272: 1470–1473.

    Article  CAS  Google Scholar 

  • Harrod R, Tang Y, Nicot C, Lu HS, Vassilev A, Nakatani Y and Giam CZ. . 1998 Mol. Cell. Biol. 18: 5052–5061.

    Article  CAS  Google Scholar 

  • Higashino F, Pipas JM and Shenk T. . 1998 Proc. Natl. Acad. Sci. USA 95: 15683–15687.

  • Jost CA, Marin MC and Kaelin Jr, WG. . 1997 Nature 389: 191–194.

    Article  CAS  Google Scholar 

  • Kaghad M, Bonnet H, Yang A, Creancier L, Biscan J-C, Valent A, Minty A, Chalon P, Lelias J-M, Dumont X, Ferrara P, McKeon F and Caput D. . 1997 Cell 90: 809–819.

    Article  CAS  Google Scholar 

  • Kao S-Y and Marriott SJ. . 1999 J. Virol. 73: 4299–4304.

  • Kiyono T, Hiraiwa A, Ishii S, Takahashi T and Ishibashi M. . 1994 J. Virol. 68: 4656–4661.

  • Marin MC, Jost CA, Irwin MS, DeCaprio JA, Caput D and Kaelin WG. . 1998 Mol. Cell. Biol. 18: 6316–6324.

    Article  CAS  Google Scholar 

  • Matsumoto K, Shibata H, Fujisawa J, Inoue H, Hakura A, Tsukahara T and Fujii M. . 1997 J. Virol. 71: 4445–4451.

  • Miyake H, Suzuki T, Hirai H and Yoshida M. . 1999 Virology 253: 155–161.

    Article  CAS  Google Scholar 

  • Mulloy JC, Kislyakova T, Cereseto A, Casareto L, LoMonico A, Fullen J, Lorenzi MV, Cara A, Nicot C, Giam C-Z and Franchini G. . 1998 J. Virol. 72: 8852–8860.

  • Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M and Ikawa S. . 1998 Nature Med. 4: 839–843.

  • Pise-Masison CA, Choi K-S, Radonovich M, Dittmer J, Kim S-J and Brady J. . 1998a J. Virol. 72: 1165–1170.

  • Pise-Masison CA, Radonovich M, Sakaguchi K, Apella E and Brady J. . 1998b J. Virol. 72: 6348–6355.

  • Rosin O, Koch C, Schmitt I, Semmes OJ, Jeang K-T and Grassmann R. . 1998 J. Biol. Chem. 273: 6698–6703.

    Article  CAS  Google Scholar 

  • Roth J, König C, Wienzek S, Weigel S, Ristea S and Dobbelstein M. . 1998 J. Virol. 72: 8510–8516.

  • Scheffner M, Werness BA, Huibregtse JM, Levine AJ and Howley PM. . 1990 Cell 63: 1129–1136.

    Article  CAS  Google Scholar 

  • Segawa K, Minowa A, Sugasawa K, Takano T and Hanaoka F. . 1992 Oncogene 8: 543–548.

  • Senoo M, Seki N, Ohira M, Sugano S, Watanabe M, Tachibana M, Tanaka T, Shinkai Y and Kato H. . 1998 Biochem. Biophys. Res. Commun. 248: 603–607.

  • Steegenga WT, Shvarts A, Riteco N, Bos JL and Jochemsen AG. . 1999 Mol. Cell. Biol. 19: 3885–3894.

    Article  CAS  Google Scholar 

  • Trink B, Okami K, Wu L, Sriuranpong V, Jen J and Sidransky D. . 1998 Nature Med. 4: 747–748.

  • Ueda Y, Hijikata M, Takagi S, Chiba T and Shimotohno K. . 1999 Oncogene 18: 4993–4998.

    Article  CAS  Google Scholar 

  • Venot C, Maratrat M, Sierra V, Conseiller E and Debussche L. . 1999 Oncogene 18: 2405–2410.

    Article  CAS  Google Scholar 

  • Werness BA, Levine AJ and Howley PM. . 1990 Science 248: 76–79.

    Article  CAS  Google Scholar 

  • Yamaoka S, Inoue H, Sakurai M, Sugiyama T, Hazama M, Yamada T and Hatanaka M. . 1996 EMBO J. 15: 873–887.

  • Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D and McKeon F. . 1998 Mol. Cell. 2: 305–316.

  • Yew PR and Berk AJ. . 1992 Nature 357: 82–85.

    Article  CAS  Google Scholar 

  • Yew PR, Liu X and Berk AJ. . 1994 Genes Dev. 8: 190–202.

Download references

Acknowledgements

We thank Dr M Hatanaka for the supply of pH2R Tax and pCMV Tax, Dr B Vogelstein for pC53-SN3, and Dr T Kiyono for pCAST2Bluc. We also thank Mr O Masui for helping our work. This work was supported in part by Grants-in-Aid for Scientific Research from Ministry of Education, Science, Sports and Culture of Japan.

Author information

Authors and Affiliations

  1. Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo-ku, 606-8507, Kyoto, Japan

    Atsushi Kaida, Yasuo Ariumi, Yoshihide Ueda, Jye-Yee Lin, Makoto Hijikata & Kunitada Shimotohno

  2. Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-0872, Japan

    Shuntaro Ikawa

Authors
  1. Atsushi Kaida
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasuo Ariumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshihide Ueda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jye-Yee Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Makoto Hijikata
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shuntaro Ikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kunitada Shimotohno
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaida, A., Ariumi, Y., Ueda, Y. et al. Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein. Oncogene 19, 827–830 (2000). https://doi.org/10.1038/sj.onc.1203387

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1203387

Keywords

This article is cited by

Search

Advanced search

Quick links