Abstract
In Caenorhabditis elegans, the vulval induction is mediated by the let-23 receptor tyrosine kinase (RTK)/Ras signaling pathway. The precise localization of the let-23 RTK at the epithelial junctions is essential for the vulval induction, and requires three genes including lin-2, -7, and -10. The mammalian homologue of lin-2 has been identified as a protein interacting with a neuronal adhesion molecule, neurexin, and named CASK. CASK has recently been reported to interact with syndecans and an actin-binding protein, band 4.1, at epithelial and synaptic junctions, and to play central roles in the formation of cell-cell junctions. The product of C. elegans lin-7 directly interacts with let-23 RTK and localize it at epithelial junctions. Here, we report three rat homologues of lin-7 ubiquitously expressed in various tissues. These homologues are accumulated at the junctional complex region in cultured Madin-Darby canine kidney cells, and are also localized at the synaptic junctions in neurons. The mammalian homologues of lin-7 may be implicated in the formation of cell-cell junctions.
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Acknowledgements
We thank Dr Kenji Takaishi (Osaka University) for the dominant active and negative Rac1 mutant MDCK cells, pCMV5 for Dr David Russell (University of Texas), and Dr Nils Brose (Max-Planck-Institut) for the anti-NMDAR1 antibody.
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Irie, M., Hata, Y., Deguchi, M. et al. Isolation and characterization of mammalian homologues of Caenorhabditis elegans lin-7: localization at cell-cell junctions. Oncogene 18, 2811–2817 (1999). https://doi.org/10.1038/sj.onc.1202652
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DOI: https://doi.org/10.1038/sj.onc.1202652
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