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Activation of the thyroid hormone receptor α gene promoter by the orphan nuclear receptor ERRα

Oncogene volume 17, pages 2429–2435 (1998)Cite this article

Abstract

The superfamily of nuclear receptors comprises transcription factors that depend on a ligand for their activity. In addition, the superfamily includes a number of orphan receptors, for which no ligand is known. We report here that the orphan receptor estrogen receptor related alpha receptor (ERRα) stimulates the expression of the thyroid hormone receptor alpha (TRα) gene promoter. We characterized a responsive site that is both necessary and sufficient for ERRα-induced transactivation. In addition, we show that both TRα and ERRα are coexpressed in embryonic intestine, brown fat and heart as well as in the adult gonads. In the testis, expression of both receptors can be found in the seminiferous tubes where it is totally restricted to spermatocytes I. Altogether this suggests that TRα is an in vivo target of ERRα.

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Author notes

  1. Jean-Marc Vanacker

    Present address: Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada

Authors and Affiliations

  1. CNRS UMR 319, Institut de Biologie de Lille, Institut Pasteur de Lille, France

    Edith Bonnelye & Cateline Delmarre

  2. CNRS UMR 49, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, Lyon, Cedex 07, 69364, France

    Jean-Marc Vanacker & Vincent Laudet

Authors
  1. Jean-Marc Vanacker
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  2. Edith Bonnelye
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  3. Cateline Delmarre
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  4. Vincent Laudet
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Vanacker, JM., Bonnelye, E., Delmarre, C. et al. Activation of the thyroid hormone receptor α gene promoter by the orphan nuclear receptor ERRα. Oncogene 17, 2429–2435 (1998). https://doi.org/10.1038/sj.onc.1202167

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  • DOI: https://doi.org/10.1038/sj.onc.1202167

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