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Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas

Oncogene volume 17, pages 123–127 (1998)Cite this article

Abstract

To determine the status of chromosome 10q23 in primary breast carcinomas, in situ and invasive carcinomas were analysed for allelic loss using microsatellite markers spanning the 10q23 region. No LOH was seen in pure intraductal carcinomas (0/20 cases). On the other hand, LOH was observed in 40% (17/42) of invasive carcinomas (P=0.0005). Interestingly, in situ lesions found in invasive tumors displayed LOH. Allelic loss was also significantly associated with loss of the estrogen receptor (P=0.011). Thus, loss of the 10q23 is strongly associated with tumor progression.

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Authors and Affiliations

  1. Department of Pathology, Medicine and Epidemiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, 10032, NY, USA

    Shikha Bose, Steven I Wang, Hanina Hibshoosh & Ramon Parsons

  2. Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, 10032, NY, USA

    Steven I Wang & Ramon Parsons

  3. Department of Epidemiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, 10032, NY, USA

    Mary Beth Terry

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  1. Shikha Bose
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  2. Steven I Wang
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Bose, S., Wang, S., Terry, M. et al. Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas. Oncogene 17, 123–127 (1998). https://doi.org/10.1038/sj.onc.1201940

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  • DOI: https://doi.org/10.1038/sj.onc.1201940

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