Abstract
The c-Abl tyrosine kinase is activated by ionizing radiation and certain other DNA-damaging agents. The DNA-dependent protein kinase (DNA–PK) and the ataxia telangiectasia mutated (ATM) gene product, effectors in the DNA damage response, contribute to the induction of c-Abl activity. The present study demonstrates that c-Abl is expressed in mouse and rat testes, and predominantly in pachytene spermatocytes of meiosis I. The results also demonstrate that c-Abl interacts directly with meiotic chromosomes. In concert with a requirement for c-Abl at the pachytene stage, we show that, in contrast to wild-type mice, testes from Abl−/− mice exhibit defects in spermatogenesis. These findings provide the first demonstration that c-Abl plays a functional role in meiosis.
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Kharbanda, S., Pandey, P., Morris, P. et al. Functional role for the c-Abl tyrosine kinase in meiosis I. Oncogene 16, 1773–1777 (1998). https://doi.org/10.1038/sj.onc.1201934
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DOI: https://doi.org/10.1038/sj.onc.1201934
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