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Association study of two interleukin-1 gene loci with essential hypertension in a Pakistani Pathan population

Journal of Human Hypertension volume 22, pages 60–62 (2008)Cite this article

An association study of IL-1 β -511C/T and IL-1 RN 86 bp VNTR polymorphisms with essential hypertension was carried out in a sample population of 500 Pakistani Pathan subjects selected randomly, comprising groups of 235 subjects with hypertension and 265 controls. The distribution of both genotypes and alleles was not statistically different in cases and controls. In conclusion, IL-1 β -511C/T and IL-1 RN 86 bp VNTR do not contribute to the aetiology of essential hypertension in the Pakistani Pathan population investigated here.

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Authors and Affiliations

  1. Medical College, Faculty of Health Sciences, Aga Khan University Medical College, Karachi, Pakistan

    M R Khawaja & F Taj

  2. Department of Biological and Biomedical Sciences, Faculty of Health Sciences, Aga Khan University Medical College, Karachi, Pakistan

    D Saleheen, U Ahmad, M O Chohan & P M Frossard

  3. Departments of Medicine and Community Health Sciences, Faculty of Health Sciences, Aga Khan University Medical College, Karachi, Pakistan

    T Jafar

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  1. M R Khawaja
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  2. F Taj
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  3. D Saleheen
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  4. U Ahmad
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  5. M O Chohan
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  6. T Jafar
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  7. P M Frossard
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Correspondence to P M Frossard.

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Khawaja, M., Taj, F., Saleheen, D. et al. Association study of two interleukin-1 gene loci with essential hypertension in a Pakistani Pathan population. J Hum Hypertens 22, 60–62 (2008). https://doi.org/10.1038/sj.jhh.1002257

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  • DOI: https://doi.org/10.1038/sj.jhh.1002257

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