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Familial aggregation and coaggregation of history of hypertension and stroke

Journal of Human Hypertension volume 19, pages 119–125 (2005)Cite this article

Abstract

We attempted to evaluate familial aggregation and coaggregation of history of hypertension and stroke. Past and family history of hypertension and stroke for 83 089 probands and their relatives were obtained from a data set for the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education (JACC Study), which was initiated from 1988 to 1990. First, evaluation was performed for familial aggregation of each of two disorders using ordinal logistic regression of the generalized estimation equations (GEE) to account for dependence of observations within families. Secondly, in order to evaluate the familial congregation of the history of hypertension and stroke, a GEE-based multivariate probed predictive model was applied. After adjusting for the proband's age, level of obesity, smoking status, drinking status, habitation area, and the gender and type of the relatives, the estimated odds ratios for the intraindividual clustering and familial aggregation of the disease history showed statistically significant relationships. In addition, the history of the two disorders showed a significant relationship in terms of familial coaggregation independently of the aggregation of each disorder itself. Our results confirmed that hypertension and stroke coaggregate strongly within families through possible effects of genetic factors, which, alone or in conjunction with environmental factors, influence susceptibility to both hypertension and stroke.

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Acknowledgements

We express our appreciation to Dr Kunio Aoki, Professor Emeritus, Nagoya University School of Medicine and the former chairman of the JACC Study Group, and Dr Haruo Sugano, former Director, Cancer Institute of the Japanese Foundation for Cancer Research, who greatly contributed to the initiation of this study. This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (C)(2) (No. 12218216) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The JACC Study was also supported by Grants-in-Aid for Scientific Research from the same Ministry (No. 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102 and 11181101).

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Authors and Affiliations

  1. Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan

    T Kondo & Y Hori

  2. Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, Nagoya, Japan

    H Toyoshima, Y Tsuzuki, H Yatsuya & K Tamakoshi

  3. Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan

    A Tamakoshi & Y Ohno

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  1. T Kondo
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  2. H Toyoshima
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  5. H Yatsuya
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  6. K Tamakoshi
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  7. A Tamakoshi
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Correspondence to H Toyoshima.

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Kondo, T., Toyoshima, H., Tsuzuki, Y. et al. Familial aggregation and coaggregation of history of hypertension and stroke. J Hum Hypertens 19, 119–125 (2005). https://doi.org/10.1038/sj.jhh.1001788

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  • DOI: https://doi.org/10.1038/sj.jhh.1001788

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