Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Effects of long-acting ACE inhibitor (temocapril) and long-acting Ca channel blocker (amlodipine) on 24-h ambulatory BP in elderly hypertensive patients

Journal of Human Hypertension volume 15, pages 643–648 (2001)Cite this article

Abstract

In a prospective randomised cross-over study, we compared the effects of ACE inhibitor temocapril and calcium channel blocker (CCB) amlodipine on ambulatory blood pressure in 59 asymptomatic elderly hypertensive patients (mean age 69 years). This study was performed in a cross-over fashion after a 2-week placebo period and 4 to 8 weeks each of treatment with temocapril and amlodipine. Of those 59 hypertensive patients, three patients with side effects and 10 patients whose office BPs did not achieve the target BPs were excluded, and the remaining 46 were analysed in this study: they consisted of 30 dippers, with a night time reduction in systolic BP (SBP) ⩾10% and 16 non-dippers, with reduction by <10%. At the baseline, there were no significant differences in the office, 24-h or daytime BPs between the two groups (dippers and non-dippers). Though the office BPs and daytime BPs were successfully controlled to the same levels with both treatments and in both dipping groups, the antihypertensive effects were stronger with the CCB than with the ACE inhibitor in the night time and morning, especially in non-dippers. We conclude that even though office BPs were controlled successfully to almost the same levels, there is a possibility that these long-acting drugs have differential antihypertensive effects on night time and morning BPs among hypertensive patients with different night time BP dipping statuses.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. O’Brien E, Sheridan J, O’ Malley K Dippers and non-dippers (letter) Lancet 1988 2 397

    Article  PubMed  Google Scholar 

  2. Kario K et alRelationships between nocturnal fall of blood pressure and silent cerebro-vascular damage in elderly hypertensives: advanced silent cerebrovascular damage in extreme-dippers Hypertension 1996 27 130–135

    Article  CAS  PubMed  Google Scholar 

  3. Shimada K et alDiurnal blood pressure variations and silent cerebrovascular damage in elderlypatients with hypertension J Hypertens 1992 10 875–878

    CAS  PubMed  Google Scholar 

  4. Verdecchia P et alAmbulatory blood pressure: an independent predictor of prognosis in essential hypertension Hypertension 1994 24 793–801

    Article  CAS  PubMed  Google Scholar 

  5. Bianchi S et alDiurnal variations of blood pressure and microalbuminuria in essential hypertension Am J Hypertens 1994 7 23–29

    Article  CAS  PubMed  Google Scholar 

  6. Staessen JA et alPredicting cardiovascular risk using conventional vs ambulatory blood pressure in olderpatients with systolic hypertension JAMA 1999 282 539–546

    Article  CAS  PubMed  Google Scholar 

  7. Lorimer AR et alDifference between amlodipine and lisinopril in control of clinic and twenty-four hour ambulatory blood pressure J Hum Hypertens 1998 12 411–416

    Article  CAS  PubMed  Google Scholar 

  8. Imai Y et alThe accuracy and performance of the A&D TM2421, a new ambulatory blood pressure monitoring device based on the cuff-oscillometric method and the korotkoff sound technique Am J Hypertens 1992 5 719–726

    Article  CAS  PubMed  Google Scholar 

  9. Devereux RB et alEchocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings Am J Cardiol 1986 57 450–458

    Article  CAS  PubMed  Google Scholar 

  10. Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure (JNC VI) Arch Intern Med 1997 157 2413–2446

    Article  Google Scholar 

  11. Canter DA, Texter MJ, McLain RW Ambulatory blood pressure monitoring can play an integral role inpatient selection, dosage adjustment and efficacy assessment in clinical trials of antihypertensive agents J Hypertens 1994 12 491–494

    Article  CAS  PubMed  Google Scholar 

  12. Litter WA, West JW Twenty-four hour action of ACE inhibitors J Hum Hypertens 1990 4 (Suppl 4) 13–16

    Google Scholar 

  13. Sierakowski B et alComparison of temocapril and atenolol in the long-term treatment if mild to moderate essential hypertension Blood Press 1997 6 229–234

    Article  CAS  PubMed  Google Scholar 

  14. Kario K, Shimada K Differential effects of amlodipine on ambulatory blood pressure in elderly hypertensivepatients with different nocturnal reductions in blood pressure Am J Hypertens 1997 10 261–268

    Article  CAS  PubMed  Google Scholar 

  15. Tatti P et alOutcome results of the Fosinopril versus Amlodipine Cardiovascular Events Randomized Trial (FACET) inpatients with hypertension and NIDDM Diabetes Care 1998 21 597–603

    Article  CAS  PubMed  Google Scholar 

  16. Estacio RO et alThe effect of nisoldipine as compared with enalapril on cardiovascular outcome inpatients with non-insulin-dependent diabetes and hypertension N Engl J Med 1998 338 645–652

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Nishiarita Kyoritu Hospital, Saga, Japan

    K Eguchi

  2. Department of Cardiology, Jichi Medical School, Tochigi, Japan

    K Eguchi, K Kario & K Shimada

Authors
  1. K Eguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K Kario
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K Shimada
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eguchi, K., Kario, K. & Shimada, K. Effects of long-acting ACE inhibitor (temocapril) and long-acting Ca channel blocker (amlodipine) on 24-h ambulatory BP in elderly hypertensive patients. J Hum Hypertens 15, 643–648 (2001). https://doi.org/10.1038/sj.jhh.1001252

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jhh.1001252

Keywords

Search

Advanced search

Quick links