Abstract
The effects of hormone replacement therapy in hypertensive women are controversial. This randomised placebo controlled trial assessed the effect of tibolone 2.5 mg on blood pressure and fasting plasma lipids in 29 hypertensive postmenopausal women over 6 months using a 2:1 randomisation to tibolone. The primary clinical end-point was mean office blood pressure. At 6 months systolic blood pressure declined by 5.30 ± 2.87% vs4.94 ± 3.37% whilst diastolic blood pressure declined 5.38 ± 2.65% vs 0.85 ± 3.69% on tibolone and placebo respectively. These differences were not statistically significant. Triglycerides decreased by 33.3 ± 6.1% vs 7.6 ± 7.9% (P < 0.01) and high-density lipoprotein (hdl)-cholesterol by 21.7 ± 3.8% vs2.4 ± 2.6% (P < 0.01) with tibolone as opposed to placebo. no significant differences were observed in total cholesterol, low-density lipoprotein (ldl)-cholesterol and lipoprotein (a). fibrinogen levels were reduced by 13.6 ± 6.8% on tibolone compared to a 19.3 ± 15.4% rise (P < 0.05) on placebo. this study suggests that tibolone has no deleterious effect on blood pressure in women with hypertension but has contrasting effects on biochemical risk factors. large-scale studies are required to determine the overall effect of tibolone on cardiovascular morbidity and mortality.
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Lloyd, G., McGing, E., Cooper, A. et al. A randomised placebo controlled trial of the effects of tibolone on blood pressure and lipids in hypertensive women. J Hum Hypertens 14, 99–104 (2000). https://doi.org/10.1038/sj.jhh.1000938
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DOI: https://doi.org/10.1038/sj.jhh.1000938
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