Abstract
Objective:
To investigate the safety and efficacy for weight loss of simmondsin, a dietary supplement extracted from the seed of the jojoba plant (Simmondsia chinensis).
Animals:
Sprague–Dawley male rats were fed various levels of simmondsin for 8 weeks (lean rats) or 16 weeks (high fat-induced obese rats).
Measurements:
Food intake, body weight and composition, histopathology, hematology parameters.
Results:
Simmondsin produced a clear dose–response effect on food intake and body weight. No remarkable histopathologic changes were noted in the liver, kidney and spleen. One lean animal, in the 0.5% group, had approximately a 20% depression in red bone marrow cells. Significant effects on hematology parameters were seen almost exclusively in groups consuming simmondsin at the highest level (0.5%) and these effects appeared to be reversed by removing simmondsin from the diet.
Conclusion:
Simmondsin at both the 0.15% level and the 0.25% level significantly reduced food intake and body weight without apparent negative effects. At dose levels much higher than therapeutic levels, there seemed to be reversible effects on circulating red and white blood cells. Future studies should determine long-term effects of lower doses on blood cell parameters.
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References
Booth AN, Elliger CA, Waiss Jr AC . Isolation of a toxic factor from jojoba meal. Life Sci 1974; 15: 1115–1120.
Verbiscar AJ, Banigan TF, Weber CW, Reid BL, Trei JE, Nelson EA et al. Detoxification of jojoba meal. J Agric Food Chem 1980; 28: 571–578.
Cokelaere MM, Dangreau HD, Daenens P, Bruneel N, Arnouts S, Decuypere EM-P et al. Investigation of possible toxicological influences of simmondsin after subacute administration in the rat. J Agric Food Chem 1992; 40: 2443–2445.
Cokelaere MM, Flo G, Lievens S, Van Boven M, Vermaut S, Decuypere EM-P . Teratological studies in defatted jojoba meal-supplemented rats. Food Chem Toxicol 2001; 39: 247–252.
Cokelaere MM, Dangreau HD, Daenens P, Arnouts S, Kuhn ER, Decuypere EM-P . Influence of pure simmondsin on the food intake in rats. J Agric Food Chem 1992; 40: 1839–1842.
Cokelaere MM, Flo G, Decuypere EM-P, Vermaut S, Daenens P, Van Boven M . Evidences for a satiating effect of defatted jojoba meal. Ind Crops Products 1995; 4: 91–96.
Flo G, Van Boven M, Vermaut S, Daenens P, Decuypere EM-P, Cokelaere MM . The vagus nerve is involved in the anorexigenic effect of simmondsin in the rat. Appetite 2000; 34: 147–151.
Cokelaere MM, Busselen P, Flo G, Daenens P, Decuypere EM-P, Kuhn ER et al. Devazepide reverses the anorexic effect of simmondsin in the rat. J Endocr 1995; 147: 473–477.
Lotti VJ, Pendleton RG, Gould RJ, Hanson HM, Chang RSL, Clineschmidt BV . In vivo pharmacology of L-364,718, a new nonpeptide peripheral cholecystokinin antagonist. J Pharm Exper Ther 1987; 241: 103–109.
Silver AJ, Flood JF, Song AM, Morley JE . Evidence for a physiological role for CCK in the regulation of food intake in mice. Am J Physiol 1989; 256: R646–R652.
York DA, Singer L, Oliver J, Abbott TP, Bray GA . The detrimental effect of simmondsin on food intake and body weight of rats. Ind Crops Products 2000; 12: 183–192.
Boozer CN, Leibel RL, Love RJ, Cha MC, Aronne LJ . Synergy of sibutramine and low dose leptin in treatment of diet-induced obesity in rats. Metabolism 2001; 50: 889–893.
Abbott TP, Holser RA, Plattner BJ, Purcell HC . Pilot-scale isolation of simmondsin and related jojoba constituents. Ind Crops Prod 1999; 10: 65–72.
Acknowledgements
We gratefully acknowledge the dedicated care of the animals by Kesha Robinson and Shiela Loanzon and the skillful carcass composition analyses by Lina Basilio. Financial support and simmondsin (‘Non-apetite’) was provided by Pharmachem Laboratories, Inc., Kearney, NJ, USA.
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Boozer, C., Herron, A. Simmondsin for weight loss in rats. Int J Obes 30, 1143–1148 (2006). https://doi.org/10.1038/sj.ijo.0803251
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DOI: https://doi.org/10.1038/sj.ijo.0803251
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