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Dairy augmentation of total and central fat loss in obese subjects

International Journal of Obesityvolume 29pages391397 (2005) | Download Citation

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Abstract

BACKGROUND AND OBJECTIVE: We have previously demonstrated an antiobesity effect of dietary Ca; this is largely mediated by Ca suppression of calcitriol levels, resulting in reduced adipocyte intracellular Ca2+ and, consequently, a coordinated increase in lipid utilization and decrease in lipogenesis. Notably, dairy Ca is markedly more effective than other Ca sources.

DESIGN: Obese subjects were placed on balanced deficit (−500 kcal/day) diets and randomized to control (400–500 mg Ca/day; n=16) or yogurt (1100 mg Ca/day; n=18) treatments for 12 weeks. Dietary macronutrients and fiber were held constant at the US average.

MEASUREMENTS: Body weight, body fat and fat distribution (by dual-energy X-ray absorptiometry), blood pressure and circulating lipids were measured at baseline and after 12 weeks of intervention.

RESULTS: Fat loss was markedly increased on the yogurt diet (−4.43±0.47 vs −2.75±0.73 kg in yogurt and control groups; P<0.005) while lean tissue loss was reduced by 31% on the yogurt diet. Trunk fat loss was augmented by 81% on the yogurt vs control diet (P<0.001), and this was reflected in a markedly greater reduction in waist circumference (−3.99±0.48 vs −0.58±1.04 cm, P<0.001). Further, the fraction of fat lost from the trunk was higher on the yogurt diet vs control (P<0.005).

CONCLUSION: Isocaloric substitution of yogurt for other foods significantly augments fat loss and reduces central adiposity during energy restriction.

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References

  1. 1

    Zemel MB, Shi H, Greer B, DiRienzo D, Zemel PC . Regulation of adiposity by dietary calcium. FASEB J 2000; 14: 1132–1138.

  2. 2

    Zemel MB . Calcium modulation of hypertension and obesity: mechanisms and implications. J Am Coll Nutr 2001; 20: 428S–435S.

  3. 3

    Zemel MB . Role of dietary calcium and dairy products in modulating adiposity. Lipids 2003; 38: 139–146.

  4. 4

    Zemel MB . Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr 2004; 79: 907S–912S.

  5. 5

    Shi H, DiRienzo D, Zemel MB . Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice. FASEB J 2001; 15: 291–293.

  6. 6

    Heaney RP . Normalizing calcium intake: projected population effects for body weight. J Nutr 2003; 133: 268S–270S.

  7. 7

    Teegarden D . Calcium intake and reduction in weight or fat mass. J Nutr 2003; 133: 249S–251S.

  8. 8

    Zemel B, Nocton AM, Richards J, Milstead A, Gebhardt L, Campbell PJ . Increasing dairy calcium intake reduces adiposity in obese African-American adults (abstract). Circulation 2002; 106 (Suppl 2): II-610.

  9. 9

    Zemel MB, Sun X, Geng X . Effects of a calcium-fortified breakfast cereal on adiposity in a transgenic mouse model of obesity (abstract). FASEB J 2001; 15: A598.

  10. 10

    Zemel MB, Geng X . Dietary calcium and yogurt accelerate body fat loss secondary to caloric restriction in aP2-agouti transgenic mice (abstract). Obes Res 2001; 9: 146S.

  11. 11

    Zemel MB, Thompson W, Milstead A, Morris K, Campbell P . Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 2004; 12: 582–590.

  12. 12

    Jacqmain M, Doucet E, Despres J-P, Bouchard C, Tremblay A . Calcium intake, body composition, and lipoprotein-lipid concentrations in adults. Am J Clin Nutr 2003; 77: 1448–1452.

  13. 13

    Albertson AM, Good CK, Holschuh NM, Eldridge EL . The relationship between dietary calcium intake and body mass index in adult women: data from the Continuing Survey of Food Intake by Individuals, 1994–96 (abstract). FASEB J 2003; 17: A289.

  14. 14

    Pereira MA, Jacobs DR, Van Horn L, Slattery ML, Kartashov AI, Ludwig DS . Dairy consumption, obesity, and the insulin resistance syndrome in young adults. The CARDIA study. JAMA 2002; 287: 2081–2089.

  15. 15

    Loos R, Rankinen T, Leon A, Skinner JS, Wilmore JH, Rao DC, Bouchard C . Calcium intake is associated with adiposity in black and white men and white women of the HERITAGE family study. J Nutr 2004; 134: 1772–1778.

  16. 16

    Shi H, Norman AW, Okamura WH, Sen A, Zemel MB . 1α-25-Dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes. FASEB J 2002; 16: 1808–1810.

  17. 17

    Boobis LH, Maughan RJ . A simple one-step enzymatic fluorometric method for the determination of glycerol in 20 μL of plasma. Clin Chim Acta 1983; 132: 173–179.

  18. 18

    Xue B, Greenberg AG, Kraemer FB, Zemel MB . Mechanism of intracellular calcium inhibition of lipolysis in human adipocytes. FASEB J 2001; 15: 2527–2529.

  19. 19

    Lin YC, Lyle RM, McCabe LD, McCabe GP, Weaver CM, Teegarden D . Dairy calcium is related to changes in body composition during a two-year exercise intervention in young women. J Am Coll Nutr 2000; 19: 754–760.

  20. 20

    Lovejoy JC, Champagne CM, Smith SR, deJonge L, Xie H . Ethnic differences in dietary intakes, physical activity, and energy expenditure in middle-aged, premenopausal women: the Healthy Transitions study. Am J Clin Nutr 2001; 74: 90–95.

  21. 21

    Buchowski MS, Semenya J, Johnson AO . Dietary calcium intake in lactose maldigesting intolerant and tolerant African-American women. J Am Coll Nutr 2002; 21: 47–54.

  22. 22

    Tanasescu M, Ferris AM, Himmelgreen DA, Rodriguez, Perez-Escamilla R . Biobehavioral factors are associated with obesity in Puerto Rican children. J Nutr 2000; 130: 1734–1742.

  23. 23

    Carruth BR, Skinner JD . The role of dietary calcium and other nutrients in moderating body fat in preschool children. Int J Obes Relat Metab Disord 2001; 25: 559–566.

  24. 24

    Skinner JD, Bounds W, Carruth BR, Ziegler P . Longitudinal calcium intake is negatively related to children's body fat indexes. JADA 2003; 103: 1626–1631.

  25. 25

    Melanson EL, Sharp TA, Schneider J, Donahoo WT, Grunwald GK, Hill JO . Relation between calcium intake and fat oxidation in adult humans. Int J Obes 2003; 27: 196–203.

  26. 26

    Davies KM, Heaney RP, Recker RR, Lappe JM, Barger-Lux MJ, Rafferty K, Hinders S . Calcium intake and body weight. J Clin Endocrinol Metabol 2000; 85: 4635–4638.

  27. 27

    Heaney RP, Davies KM, Bargar-Lux MJ . Calcium and weight: clinical studies. J Am Coll Nutr 2002; 21: 152S–155S.

  28. 28

    McCarron DA . Calcium and magnesium nutrition in human hypertension. Ann Intern Med 1983; 98: 800–805.

  29. 29

    Drapeau V, Despres J-P, Bouchard C, Allard L, Fournier G, Leblanc C, Tremblay A . Modifications in food-group consumption are related to long-term body weight changes. Am J Clin Nutr 2004; 80: 29–37.

  30. 30

    Barr SI . Increased dairy product or calcium intake: is body weight or composition affected in humans? J Nutr 2003; 133: 245S–248S.

  31. 31

    Parikh S, Yanovski JA . Calcium intake and adiposity. Am J Clin Nutr 2003; 77: 281–287.

  32. 32

    Seckl JR, Walker BR . 11 β-Hydroxysteroid dehydrogenase Type 1—a tissue-specific amplifier of glucocorticoid action. Endocrinology 2001; 142: 1371–1376.

  33. 33

    Rask E, Olsson T, Soderberg S, Andrew R, Livingstone DE, Johnson O, Walker BR . Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metabol 2001; 86: 1418–1421.

  34. 34

    Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS . A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 294: 2166–2170.

  35. 35

    Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Shart MGF, Fleming S, Mullins JJ, Seckl JR, Flier JS . Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest 2003; 112: 83–90.

  36. 36

    Kotelevstev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ . 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia in obesity or stress. Proc Natl Acad Sci USA 1997; 94: 14924–14929.

  37. 37

    Zemel MB, Sobhani T . Intracellular calcium modulation of cortisol production in human adipocytes (abstract). FASEB J 2003; 17: A323.

  38. 38

    Morris KL, Miller SL, Zemel MB . Calcitriol regulation of 11-β hydroxysteroid dehydrogenase 1 (11-β-HSD1) and angiotensin II receptor 1 (AT1) expression in human adipocytes (abstract). FASEB J 18; 585: 11.

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Acknowledgements

This research was supported by the Bell Institute of Health and Nutrition, General Mills Inc.

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Affiliations

  1. Department of Nutrition, The University of Tennessee, Knoxville, TN, USA

    • M B Zemel
    • , J Richards
    • , A Milstead
    •  & L Gebhardt
  2. Childrens Hospital, Knoxville, TN, USA

    • S Mathis
  3. Bell Institute for Health and Nutrition, General Mills Inc., Golden Valley, MN, USA

    • E Silva

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Correspondence to M B Zemel.

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https://doi.org/10.1038/sj.ijo.0802880

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