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Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet

International Journal of Obesity volume 28, pages 1509–1513 (2004)Cite this article

Abstract

OBJECTIVE: Apolipoprotein (apo) A-IV is an antiatherogenic apolipoprotein, which may be involved in the regulation of food intake. Plasma apoA-IV is elevated in human obesity and apoA-IV polymorphisms have been associated with the extent of obesity. Our aim was to determine the effects of weight loss on plasma apo-IV in obese adolescents and to examine the relation of apoA-IV with the degree of obesity.

DESIGN: Longitudinal intervention study of a low fat hypocaloric diet conducted in a dietary camp.

SUBJECTS: Two groups of obese adolescents (n=47 and n=29), age: 12.7±1.7 and 11.7±2.6 y, relative body mass index (RBMI): 168±24 and 175±34%, respectively.

MEASUREMENTS: Plasma total apoA-IV, apoA-I, apoB, plasma distribution of apoA-IV, leptin, lipids, and lipoproteins before and after 3 weeks of weight reduction.

RESULTS: Plasma apoA-IV decreased from 11.5±4.1 mg/dl before to 6.7±2.2 mg/dl after weight reduction in the first group (P<0.001) and to a similar extent in the second group. The relative amount of lipid-free apoA-IV and apoA-IV associated with apoA-I increased slightly, whereas apoA-IV associated with lipoproteins devoid of apoA-I decreased. ApoA-IV levels before and after weight reduction and the changes in plasma apoA-IV did not independently correlate with RBMI, weight loss, or plasma leptin.

CONCLUSION: Plasma apoA-IV decreases markedly in overweight adolescents undergoing short-term weight reduction. The decrease is not directly related to the degree of weight loss and the mechanisms underlying this reduction remain to be clarified.

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Acknowledgements

This study was supported by the Jubliäumsfonds der Österreichischen Nationalbank (Project #8830 to W Strobl and Project #9331 to F Kronenberg) and in part by the Austrian Science Fund (Project #13649 BIO to W Strobl).

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Authors and Affiliations

  1. Institute of Medical Biology and Human Genetics, Medical University of Innsbruck, Innsbruck, Austria

    A Lingenhel & F Kronenberg

  2. Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria

    C Eder, H Stangl & W Strobl

  3. Department of Pediatrics, a.ö. Krankenhaus St Pölten, St Pölten, Austria

    K Zwiauer

  4. Institute of Epidemiology, GSF-National Research Center for Environment and Health, Neuherberg, Germany

    F Kronenberg

  5. Department of Clinical Chemistry, Landeskrankenanstalten Salzburg, Salzburg, Austria

    W Patsch

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  1. A Lingenhel
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  2. C Eder
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  3. K Zwiauer
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  4. H Stangl
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  7. W Strobl
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Correspondence to W Strobl.

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Lingenhel, A., Eder, C., Zwiauer, K. et al. Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet. Int J Obes 28, 1509–1513 (2004). https://doi.org/10.1038/sj.ijo.0802789

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