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Success rate of Orlistat in primary-care practice is limited by failure to follow prescribing recommendations: the referral letter content vs clinical reality

Abstract

Numerous referrals to our Obesity Unit state that ‘treatment with Orlistat did not work’. This surprised us, since Orlistat has been well documented to result in long-term sustained moderate weight loss. A simple questionnaire to 70 such patients, however, revealed that in many cases the referral physician had not observed basic rules and regulations, nor given appropriate information on Orlistat use.

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References

  1. Apfelbaum M, Vague P, Ziegler O, Hanotin C, Thomas F, Leutenegger E . Long-term maintenance of weight loss after a very-low-calorie diet: a randomized blinded trial of the efficacy and tolerability of sibutramine. Am J Med 1999; 106: 179–184.

    Article  CAS  Google Scholar 

  2. James WP, Astrup A, Finer N, Hilsted J, Kopelman P, Rössner S, Saris WHM, Van Gaal LF, for the STORM study Group.Effect of sibutramine on weight maintenance after weight loss: a randomized trial. Lancet 2000; 356: 2119–2125.

    Article  CAS  Google Scholar 

  3. Hill JO, Hauptman J, Anderson JW, Fujioka K, O'Neil PM, Smith DK, Aronne LJ . Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: a 1-y study. Am J Clin Nutr 1999; 69: 1108–1116.

    Article  CAS  Google Scholar 

  4. Sjostrom L, Rissanen A, Andersen T, Boldrin M, Golay A, Koppeschaar HP, Krempj M . Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Lancet 1998; 352: 167–172.

    Article  CAS  Google Scholar 

  5. Rössner S, Sjöström L, Noack R, Meinders E, Noseda G . Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity. Obes Res 2000; 8: 49–61.

    Article  Google Scholar 

  6. Lindgärde F . The effect of orlistat on body weight and coronary heart disease risk profile in obese patients: the Swedish Multimorbidity Study. J Intern Med 2000; 248: 245–254.

    Article  Google Scholar 

  7. Linné Y, Rössner S . Short Communication. Referral letters to an obesity unit—relationship between doctor and patient information. Int J Obes Relat Metab Disord 2000; 24: 1379–1380.

    Article  Google Scholar 

  8. Womble LG, Wadden TA, Berkowitz RI, Sarwer DB, Rothman RA . Long-term medication use and weight loss maintenance: an observational study. Obes Res 2001; 9: 652–653.

    Article  CAS  Google Scholar 

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Linné, Y., Rooth, P. & Rössner, S. Success rate of Orlistat in primary-care practice is limited by failure to follow prescribing recommendations: the referral letter content vs clinical reality. Int J Obes 27, 1434–1435 (2003). https://doi.org/10.1038/sj.ijo.0802401

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