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  • Genetics of Obesity
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Association between polymorphisms in candidate genes and morbid obesity

International Journal of Obesity volume 25, pages S19–S21 (2001)Cite this article

Abstract

Polymorphisms in a number of candidate genes have been reported to be associated with obesity. We have determined the incidence of the following polymorphisms in the following candidate genes in a group of 388 morbid obese patients (mean body mass index (BMI) 52±8.01) who underwent gastric banding surgery: lipoprotein lipase (LpL) t-93 g and N291S; peroxisome proliferator receptor γ (PPARγ), P12A, P115Q and c1431t; peroxisome proliferator receptor α (PPARα) L162V; β-adrenergic receptor 2 (β-AR 2), Q27E; β-adrenergic receptor 3 (β-AR 3) W64R; uncoupling protein 1 (ucp-1), a-3826g, ucp-2, 45 bp insertion. Only for the ucp2 polymorphism did we find a statistically significant association with obesity. The β-AR 3 W64R and ucp-1 a-3826g polymorphisms influenced the rate of the development of obesity and may act synergistically.

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Authors and Affiliations

  1. Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany

    D Evans, S Ahle & U Beisiegel

  2. Klinik für Allgemeinchirurgie, Evangelisches und Johanniter Klinikum, Dinslaken, Germany

    AM Wolf, U Nellessen, B Kortner & HW Kuhlmann

Authors
  1. D Evans
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  2. AM Wolf
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  3. U Nellessen
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  4. S Ahle
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  5. B Kortner
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  6. HW Kuhlmann
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  7. U Beisiegel
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Correspondence to D Evans.

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Evans, D., Wolf, A., Nellessen, U. et al. Association between polymorphisms in candidate genes and morbid obesity. Int J Obes 25 (Suppl 1), S19–S21 (2001). https://doi.org/10.1038/sj.ijo.0801690

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  • DOI: https://doi.org/10.1038/sj.ijo.0801690

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