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Intrapair resemblance in very low calorie diet-induced weight loss in female obese identical twins

International Journal of Obesity volume 24, pages 1051–1057 (2000)Cite this article

Abstract

OBJECTIVE: To assess intrapair resemblance in changes of body weight, total body fat, fat distribution, resting metabolic rate, fasting respiratory quotient and cardiovascular disease risk factors in response to therapeutic weight loss in female obese identical twins.

DESIGN: Patients stayed for 40 days on an inpatient metabolic unit under careful supervision. The stay was divided into three parts: an initial period of 7 days for adjustment to the hospital environment and for baseline measurements, 28 days of the weight reduction regimen when negative energy balance was achieved mainly by a very low calorie diet (1.6 MJ per day) and 5 days of testing after weight reduction.

SUBJECTS: Fourteen pairs of premenopausal female obese identical twins (age: 39.0±1.7 y; body weight (BW): 93.9±21.2 kg; body mass index (BMI): 34.2±7.8 kg/m2) participated in the study.

MEASUREMENTS:. Before and after weight loss, the following measurements were made: body composition by anthropometry and hydrodensitometry, intra-abdominal fat by ultrasonography, resting metabolic rate by indirect calorimetry. Total cholesterol, high-density lipoprotein-cholesterol, triglycerides and uric acid were determined by standard laboratory procedures. Blood pressure was measured in the morning in the recumbent position.

RESULTS: Subjects lost 8.8±1.9 kg of weight, from 93.9±21.2 to 85.1±10.9 kg (P<0.0001) and 6.5±2.3 kg of body fat (P<0.001). Weight losses varied widely among subjects, with a high correlation between losses of members of twin pairs for body weight (r=0.85; P<0.001) and for body fat (r=0.88; P<0.0001). Changes in uric acid resulting from weight loss were also correlated among members of twin pairs whereas changes in blood pressure, cholesterol and triglycerides were not.

CONCLUSION: The great intrapair resemblance observed in very low calorie diet-induced weight and fat losses in female obese identical twins suggests an important role of genetic factors in response to the weight reduction regimen.

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References

  1. Zhang YU, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM . Positional cloning of the mouse OB gene and its human homologue Nature 1994 372: 425–432.

    Article  CAS  Google Scholar 

  2. Pérusse L, Chagnon YC, Weisnagel J, Bouchard C . The human obesity gene map: the 1998 update Obes Res 1999 7: 111–129.

    Article  Google Scholar 

  3. Montague CT, Farooqui IS, Whitehead JT, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst IA, Cheetham CJ, Earley AR, Barnett AH, Prins JP, O'Rahilly S . Congentital leptin deficiency is associated with severe early-onset obesity in humans Nature 1997 387: 903–908.

    Article  CAS  Google Scholar 

  4. Comuzzie AG, Allison DA . The search for human obesity genes Science 1998 280: 1374–1377.

    Article  CAS  Google Scholar 

  5. Pérusse L, Tremblay A, Leblanc C, Cloninger CR, Reich T, Rice J, Bouchard C . Familial resemblance in energy intake: contribution of genetic and environmental factors Am J Clin Nutr 1988 47: 629–635.

    Article  Google Scholar 

  6. Tarusk V, Beaton GH . The nature and individuality of within-subjects variation in energy intake Am J Clin Nutr 1991 54: 464–470.

    Article  Google Scholar 

  7. Bouchard C, Pérusse L . Genetics of obesity Ann Rev Nutr 1993 13: 337–354.

    Article  CAS  Google Scholar 

  8. Ravussin F, Bogardus C . Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization Am J Clin Nutr 1989 49: 968–975.

    Article  CAS  Google Scholar 

  9. Roberts SB, Savage J, Coward WA, Chow B, Lucas A . Energy expenditure and intake in infants born to lean and overweight mothers New Engl J Med 1988 318: 461–466.

    Article  CAS  Google Scholar 

  10. Bouchard C, Tremblay A, Després JP, Nadeau A, Lupien PJ, Thériault G, Duussuault J, Moorjani S, Pinault S, Fournier G . The response to long-term overfeeding in identical twins New Engl J Med 1990 322: 1477–1482.

    Article  CAS  Google Scholar 

  11. Bouchard C, Tremblay A, Despres JP, Thériault G, Nadeau A, Lupien PJ, Moorjani S, Prudhomme D, Fournier G . The response to exercise with constant energy intake in identical twins Obes Res 1994 2: 44–410.

    Article  Google Scholar 

  12. Bouchard C, Tremblay A, Després J-P, Nadeau A, Lupien PJ, Moorjani S, Thériault G, Kim SY . Overfeeding in identical twins: 5-year postoverfeeding results Metabolism 1996 45: 1042–1050.

    Article  CAS  Google Scholar 

  13. Hainer V, Kunesova M, Stich V, Parizkova J, Zak A, Wernischova V, Kozich P, Hrabak P, Dedicova L . Very low energy formula diet in the treatment of obesity Int J Obes 1989 13 (Suppl 2): 185–188.

    PubMed  Google Scholar 

  14. Hainer V, Stich V, Kunesova M, Parizkova J, Zak A, Wernischova V, Stukavec V . Body fat distribution, metabolic and hormonal indices in obese patients treated initially by very low calorie diet. In: Romsos DR, Himms-Hagen J, Suzuki M (eds). Obesity: diettary factors and control Japan Scientific Press: Tokyo and Karger: Basel, 1991, pp 215–226.

    Google Scholar 

  15. Food and Nutrition Board. Recommended Dietary Allowances, 9th edn. National Research Council, NAS: Washington, DC, 1980.

  16. Meneely GR, Kaltreider NL . The volume of the lung determined by helium dilution, description of the method and comparison with other procedures J Clin Invest 1949 28: 129–139.

    Article  CAS  Google Scholar 

  17. Heymsfield SE, Tighe A, Wang ZM . Nutritional assessment by anthropometric and biochemical methods. In: Shils ME, Olson JA, Shike M (eds). Modern nutrition in health and disease Lea & Febiger: Philadelphia, PA 1994, pp 812–841.

    Google Scholar 

  18. Lohman TG, Roche AF, Martorell R . Anthropometric standardization reference manual. Human Kinetics: Champaign, IL, 1991,pp 39–70.

  19. Measuring obesity—classification and description of anthropometric data. Report on a WHO consultation on the epidemiology of obesity, Warsaw, 1987, pp 24–51.

  20. Parizkova J . Body fat and physical fitness. Nijhoff M: The Hague 1977 pp 32–36.

  21. Armellini F, Zamboni M, Rigo L, Todesco T, Bergamo-Andreis IA, Procacci C, Bosello O . The contribution of sonography to the measurement of intraabdominal fat J Clin Ultrasound 1990 18: 563–567.

    Article  CAS  Google Scholar 

  22. Tornaghi G, Raiteri R, Pozzato C, Rispoli A, Bramani M, Cipolat M, Craveri A . Anthropometric or ultrasonic measurements in assessment of visceral fat? A comparative study Int J Obes Relat Metab Disord 1994 18: 771–775.

    CAS  PubMed  Google Scholar 

  23. Kunesova M, Hainer V, Hergetova H, Parizkova J, Horejs J, Stich V . Simple anthropometric measurements—relation to body fat mass, visceral adipose tissue and risk factors of atherogenesis Sborn lek 1995 96: 257–268.

    CAS  PubMed  Google Scholar 

  24. Shroutt PE, Fleiss JL . Intraclass correlation: uses in assessing rater ability Psychol Bull 1979 86: 420–428.

    Article  Google Scholar 

  25. Poehlman ET, Tremblay A, Nadeau A, Dussault J, Thériault G, Bouchard C . Heredity and changes in hormones and metabolic rates with short-term training Am J Physiol 1986 250: E711–E717.

    CAS  PubMed  Google Scholar 

  26. Heller DA, de Faire U, Pedersen NL, Dahlen G, McClearn GE . Genetic and environmental influences on serum lipid levels in twins New Engl J Med 1993 328: 1150–1156.

    Article  CAS  Google Scholar 

  27. Uusitupa M, Laakso M, Sarlund H, Majander H, Takala J, Penttila I . Long term effects of a very low calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese noninsulin-dependent diabetics Int J Obes 1989 13 (Suppl 2): 163–1644.

    PubMed  Google Scholar 

  28. Anderson JW, Hamilton CC, Brinkman-Kaplan V . Benefits and risks of an intensive very-low- calorie diet program for severe obesity Am J Gastroenterol 1992 87: 6–15.

    CAS  PubMed  Google Scholar 

  29. Reisin E, Frohlich EDS, Messerli FH, Dreslinski GR, Dunn FG, Jones MM, Batson HM Jr . Cardiovascular changes after weight reduction in obesity hypertension Ann Intern Med 1983 98: 315–319.

    Article  CAS  Google Scholar 

  30. Kanders BS, Blackburn GL . Very-low-calorie diets for the treatment of obesity. In: Blackburn OL, Kanders BS (eds) Obesity, pathophysiology, psychology, and treatment. Chapman and Hall: New York 1993, pp 197–216.

  31. Voliovitch H, Magazanic A, Voliovitch I, Blachar Y, Rudniki C, Zahavi I . Very low calorie diets—clinical trial Int J Obes 1989 13 (Suppl 2): 157.

    PubMed  Google Scholar 

  32. Schotte DE, Stunkard AJ . The effects of weight reduction on blood pressure in 301 obese patients Arch Intern Med 1990 150: 1701–1704.

    Article  CAS  Google Scholar 

  33. Grilo CM, Pogue-Geile MF . The natures of environmental influences on weight and obesity: behavioral genetic analysis Psychol Bull 1991 110: 520–537.

    Article  CAS  Google Scholar 

  34. Maes HM, Neale MC, Eaves LJ . Genetic and environmental factors in relative body weight and human adiposity Behav Genetics 1997 27: 325–351.

    Article  CAS  Google Scholar 

  35. Austin MA, Friedlander Y, Newman B, Edwards K, Mayer-Davis EJ, King MC . Genetic influences on changes in body mass index: a longitudinal analysis of women twins Obes Res 1997 5: 326–331.

    Article  CAS  Google Scholar 

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Acknowledgements

This study was supported in part by grants IGA MZ CR 6 4311-3 from the Czech Ministry of Health, the Danone Institute and R03-TW-00561-01 from the NIH.

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Authors and Affiliations

  1. 3rd Department of Internal Medicine, Obesity Unit, The First Medical Faculty, Charles University, Prague, 128 08, Czech Republic

    V Hainer, M Kunešová, J Parízková & V Štich

  2. Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104, PA, USA

    AJ Stunkard

  3. Obesity Research Center, St Luke's/Roosevelt Hospital, New York, 10025, NY, USA

    DB Allison

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Correspondence to V Hainer.

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Hainer, V., Stunkard, A., Kunešová, M. et al. Intrapair resemblance in very low calorie diet-induced weight loss in female obese identical twins. Int J Obes 24, 1051–1057 (2000). https://doi.org/10.1038/sj.ijo.0801358

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