Volume 43

  • No. 8 August 2022

    Sapidolide A (SA) treats acetaminophen-induced liver injury (AILI) by inhibiting NLRP3 inflammasome activation in macrophages. Acetaminophen (APAP) causes hepatocyte necrosis, which releases DAMPs and induces NLRP3-inflammasome-mediated macrophage pyroptosis. This leads to the secretion of pro-inflammatory factors, such as IL-1β and IL-18, that further recruits immune cells and aggravates liver inflammation, as well as hepatocyte damage. SA acts as an inhibitor of NF-κB signaling, NLRP3 inflammasome activation, and pyroptosis in macrophages, thereby reducing inflammation and protecting against AILI.

  • No. 7 July 2022

    This work discovered that depletion of Clk1 significantly suppressed methamphetamine-induced reward behaviors in Clk1+/- mutation mice, which was accompanied by elevated expression of dopamine transporter (DAT).  It was further demonstrated that HIF-1α-mediated change in iron homeostasis is involved in the Clk1 deficiency-altered DAT expression by interrupting its degradation.

  • No. 6 June 2022

    Schematic diagram showing how metformin promotes SCI (spinal cord injury) recovery. After SCI, metformin treatment not only reverses the SCI-induced blockade of autophagic flux in microglial cells, but also promotes the transformation of microglial cells from M1 to M2 phenotype polarization, subsequently enhancing the myelin debris clearance, which consequently promotes myelin preservation and nerve repair following SCI.

  • No. 5 May 2022

    Bile acids are important mediators for lipid absorption, distribution, and metabolism through activation of bile acid receptor FXR. Disregulation in bile acid homeostasis and FXR function resulted in NASH. The cover art dipicts the role of FXR in bile acid regulation and the FXR structure as the basis for rational drug design for treating NASH, both topics are reviewed by Jiao et al and by Tian et al in pages 1103 and 1120, respectively.

  • No. 4 April 2022

    Through computational predictions and successive experimental validations, a few natural products were discovered to potentially block the infection of SARS-CoV-2 by interrupting the binding between the viral spike protein and human receptor ACE2.

  • No. 3 March 2022

    Sun Wukong, also known as Qitiandasheng, a character with tremendous magic power and is almost immortal after eating a kind of legendary fruit named "Renshenguo". We thus select Sun Wukong for illustration of the strong anti-heart aging efficacy of Emodin and Kanglexin. Kanglexin displays stronger efficacy than Emodin because of its more potent binding affinity to Parkin.

  • No. 2 February 2022

    Proposed mechanism by which orosomucoid (ORM) is involved in adipose tissue fibrosis. ORM1-deficient mice showed significant increases in fat mass and excessive collagen deposition. Exogenous administration of ORM activates adipose tissue AMPK, inhibits TGF-β1 levels, and reduces the expression of collagen and extracellular matrix (ECM) mediators, thus alleviating adipose tissue fibrosis. See the article in pages 367–375.

  • No. 1 January 2022

    Benzimidazoles are promising candidates for the treatment of GBM via arresting cell cycle and inducing concurrent apoptotic and pyroptotic cell death. It is of great importance to develop benzimidazoles for combination therapy or as alternative drugs for GBM patients who are resistant or less responsive to temozolomide.