Volume 42

  • No. 6 June 2021

    Challenges and opportunities for network pharmacology-based research on traditional Chinese medicines against COVID-19. See the article in pages 845–847.

  • No. 5 May 2021

    Drp1 can be SUMOylated by both SUMO-1 and SUMO-2/3. SUMO-1-ylation and deSUMO-2/3-ylation of Drp1 promotes its association with mitochondrial outer membrane (MOM), which facilitates mitochondrial fission and activates mitophagy. On the contrary, SUMO-2/3-ylation and deSUMO-1-ylation of Drp1 lead to accumulation of defective mitochondria and cardiomyocyte apoptosis.

  • No. 4 April 2021

    NcRNAs involved in different mechanisms of DOX-induced cardiac cell apoptosis. MiR-499-5p and miR-532-3p regulate DOX-induced mitochondrial fission; miR-15b-5p, miR-23a, miR-29b, miR-146a and LincRNA-p21 regulate the DOX-induced decline in mitochondrial membrane potential and cytochrome c release; miR-15b-5p, miR-23a, miR-30 and LincRNA-p21 regulate DOX-induced ROS production; miR-140-5p, miR-451 and LincRNA-p21 regulate DOX-induced change of antioxidant levels; miR-378 regulates DOX-induced ER stress; miR-320a regulates the DOX-induced impact on microvessel density; miR-21, miR-34a-5p, miR-130a, miR-208a, miR-212/132, Linc00339, LncRNA CHRF, LncRNA Mhrt and CircRNA derived from the Ttn 105-111 gene regulate DOX-induced apoptosis with no clearly indicated mechanisms; and LncRNA FOXC2-AS1 regulates DOX-induced reduction in cell viability.

  • No. 3 March 2021

    The progress of tumor metastasis is accompanied with significant mechanical changes of multifaceted factors, including cancerous cells and a wide range of microenvironmental cues. In this article, Li et al summarized the advances of atomic force microscopy (AFM) in revealing multiple types of micro/nanoscale mechanics associated with tumor development and metastasis.

  • No. 2 February 2021

    The E3 ligases engage in the malignancy of UM. a MiR-17-3p inhibits MDM2-mediated degradation of TP53 through the UPS. However, LncRNA PVT1 in UM could disturb miR-17-3p-mediated inhibition of MDM2. b SKP2-mediated degradation of CDKN1B through the UPS induces UM growth. c Hypoxia induces transactivation of HIF1A that could be degraded through VHL-mediated UPS in normoxia. d RNF2-mediated ubiquitination of histone H2A executes completely different regulation of downstream genes in UM versus other tissues. e MYCBP2 elevates the sensitivity of UM cells to Trail-induced apoptosis by conjugating to C-MYC. However, miR-92a-3p overexpressed in UM reduces the protein level of MYCBP2. See the article in pages 179–188.

  • No. 1 January 2021

    Immunotherapy has achieved great outcome in clinic, and PD-1/PD-L1 immunotherapy is the most promising one. Due to the limitations of monoclonal antibodies, the discovery of small molecule drugs blocking PD-1/PD-L1 signaling has attracted great interest. In this issue, Wu et al summarized the advances in small molecule inhibitors targeting the PD-1/PD-L1.