Volume 42 Issue 11, November 2021

NLRP3 inflammasome is implicated in inflammation-associated diseases such as multiple sclerosis. Liao et al. identified 1,2,4-TTB as a selective NLRP3 inflammasome inhibitor, which inhibited the aggregation of NLRP3 and ameliorated EAE progression and demyelination. This image illustrates the mechanism that 1,2,4-TTB inhibits NLRP3 inflammasome and the progression of EAE. See the article in pages 1769–1779.

Review Article

Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications

Hai-feng Hu
Zeng Ye
Shun-rong Ji
Review Article 11 Feb 2021
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NOD-like receptors in autoimmune diseases

Li Chen
Shi-qi Cao
Jian-ping Zuo
Review Article 15 Feb 2021

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Article

Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media

Peng Zeng
Qiu-hong Hua
Ru Zhang
Article Open Access 05 Feb 2021
1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis

Rui-yuan Pan
Xiang-xi Kong
Ya-jin Liao
Article 24 Feb 2021
Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-κB-dependent suppression of SERCA2a and Cav1.2 expression

Take home Figure. IL-17 promotes the development of heart failure. Upregulation of IL-17 activates NF-κB, which in turn suppresses the expression of CACNA1C encoding the pore-forming subunit of voltage gated Ltype calcium channel Cav1.2 and ATP2A2 encoding SERCA2a. Decreased expression of Cav1.2 and SERCA2a reduced cardiac contractility due to impaired calcium handling and promoted cardiac hypertrophic growth through the activation of calcium related signaling pathway, which eventually led to heart failure. PLN, phospholamban; SERCA2a, sarcoplasmic reticulum Ca²⁺-ATPase2a; RYR2, ryanodine receptor 2; CAMKII, calcium/calmodulin-dependent kinase II

Gen-long Xue
De-sheng Li
Zhen-wei Pan
Article 15 Feb 2021
Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43

Jia-dan Wang
Ying Shao
Dan-yan Zhu
Article Open Access 05 Feb 2021
Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats

Chao Ye
Ying Tong
Guo-qing Zhu
Article 15 Feb 2021
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation

Zhen-ning Lu
Wei-xiao Niu
Hong-wei He
Article 31 Aug 2021
Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation

Jin-dong Zhang
Jiao Liu
Li-ping Duan
Article Open Access 08 Feb 2021
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice

Yu-ran Ren
Yang-liang Ye
Ying Leng
Article 11 Feb 2021
Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis

Cheng-lin Li
Juan Li
Xiao-xing Yin
Article 20 Apr 2021
Identification of pimavanserin tartrate as a potent Ca²⁺-calcineurin-NFAT pathway inhibitor for glioblastoma therapy

Zhen-zhen Liu
Xiao-ning Liu
Bo Tang
Article 06 Aug 2021
Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin

Xiao-ming Huang
Jia-jun Huang
Wen-zhe Ma
Article 19 Feb 2021
The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53

Wen-fang Li
Arin Herkilini
Shou-rong Wu
Article 01 Feb 2021
G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3β and stabilizing β-catenin

Cong-hui Zhang
Hong Liu
Rong-guang Shao
Article 03 Feb 2021
Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases

An-te Ou
Jia-xin Zhang
Yong-zhuo Huang
Article 24 Sept 2021
Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1

Wan-ting Zhang
Ting-ting Liu
Yong Geng
Article Open Access 25 Feb 2021
Ginsenoside 20(S)-Rh2 promotes cellular pharmacokinetics and intracellular antibacterial activity of levofloxacin against Staphylococcus aureus through drug efflux inhibition and subcellular stabilization

Xiao-yang Chen
Fei Qian
Jing-wei Zhang
Article 30 Aug 2021
Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins

Tong Wu
Yun Sheng
Li Liu
Article 08 Feb 2021

Top of page ⤴

Volume 42 Issue 11, November 2021

Review Article

Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications

NOD-like receptors in autoimmune diseases

Article

Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media

1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis

Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-κB-dependent suppression of SERCA2a and Cav1.2 expression

Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43

Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats

Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation

Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation

SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice

Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis

Identification of pimavanserin tartrate as a potent Ca²⁺-calcineurin-NFAT pathway inhibitor for glioblastoma therapy

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin

The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53

G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3β and stabilizing β-catenin

Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases

Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1

Ginsenoside 20(S)-Rh2 promotes cellular pharmacokinetics and intracellular antibacterial activity of levofloxacin against Staphylococcus aureus through drug efflux inhibition and subcellular stabilization

Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins

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