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High-efficiency organic light-emitting devices usually require the growth of many layers of different materials by vapour deposition in vacuum. Naoya Aizawa et al. demonstrate the fabrication of high-efficiency multilayer organic LEDs from solution.
Short telomeres are risk factors for age-associated diseases such as cardiopathies. Here the authors show that cardiac reactivation of telomerase, the telomere-elongating enzyme whose expression is normally silenced postnatally, mitigates the consequences of myocardial infarction in adult mice.
Epithelial cells must position their mitotic spindle correctly to maintain cell–cell adhesion. Here Vitiello et al. show that the tumour suppressor DLC2 and the mitotic kinesin Kif1b coordinate microtubule–actin interactions upstream of mDia3, guiding spindle positioning and mitotic fidelity.
Super-resolution optical fluctuation imaging provides 3D images of biological specimens via blinking fluorophores. Geissbuehler et al. present a multiplexed version of this method that captures images at multiple focal planes simultaneously, reducing the acquisition time compared with standard approaches.
Two-dimensional photocurrent spectroscopy can identify coherent electronic dynamics and offers promise for studies of numerous material systems. Karki et al. now show that the method can be used to study ultrafast carrier processes in lead sulphide quantum dots, such as multiple exciton generation.
Superconducting circuits are one possible way of realizing qubits, but the time for which they can maintain their quantum state is limited by single-electron-like excitations. Wang et al. now demonstrate a technique for controlling these so-called quasiparticles and improving qubit lifetime.
Graphene is famous for its Dirac cone electronic structure, which leads to peculiar charge transport properties. Here, Adjizian et al. search for its counterparts in organic materials and propose a family of two-dimensional networks of conjugated polymers that are ready to be tested in experiments.
Histone modification is critical for gene expression regulation during development. Here, the authors show that the demethylase LSD1 and its target gene ATN1are responsible for maintenance of neural progenitor cells during mouse cortical development.
Marine sedimentary 231Pa/230Th ratios are considered a promising tool for the investigation of past modes of ocean circulation. Here, the authors present a compilation of new and existing Atlantic sedimentary 231Pa/230Th ratios and interpret these data in the context of abrupt cooling during Heinrich Stadial 1.
The nature of the relationship between the spin-ordered and superconducting states of the cuprates is a longstanding puzzle. X-ray measurements conducted by Guarise et al. suggest that a continuum model rather than overdamped magnon model provides a more complete picture of the spin spectrum of Bi2Sr2CaCu2O8+δ.
Current genetic mouse models of lung cancer develop multifocal tumours in all lobes, which limits their applicability to model radiotherapy of human disease. Here Herter-Sprie et aldevelop a method to induce single lung tumours in these models, allowing precise evaluation of radiation regiment efficacy.
Following fertilization, the oocyte and sperm lose their distinct chromatin signature to form a functional embryonic genome. Here the authors find that, in human embryos, the paternal constitutive heterochromatin is inherited in the canonical configuration from the sperm and is propagated by the H3K9/HP1 pathway.
Regulation of CD4 and CD8 expression during thymic development is a classical model to study control of lineage determination. Here the authors show that Brd1 epigenetically marks CD8 enhancer for activation by mediating H3K14 acetylation, which is necessary for establishing the CD8 T-cell lineage.
Effective treatment options for mitochondrial diseases are scarce. Here, Aiyar et al. identify the TIM23 mitochondrial protein sorting machinery as a potential intervention point for mitochondrial ATP synthase disorders.
Executive functions are affected by ageing but it is unclear how. Kievit et al.use brain imaging and modelling approaches to show how multifactorial explanations outperform single-factor models when relating age-related differences in grey and white matter to differences in fluid intelligence and multitasking.
Integrins are activated by binding to the cytoskeletal adaptor talin, but the mechanisms guiding activation are unclear. Here Yang et al.show that the Rap1 effector RIAM binds to the integrin-binding head of talin to promote integrin activation, perhaps by sterically interfering with talin autoinhibition.
Rapidly switching the focus of attention is believed to impair memory, but it is unclear how. Lewis-Peacock and Norman use brain imaging and multivariate analysis to show that when two memories briefly and closely compete in the brain, there is a lasting impairment in the ability to remember these thoughts.
ZrO2 is known to be a very poor glass former, namely an extremely fragile liquid, while its high melting temperature impedes a mechanistic understanding. Here, Kohara et al. show the absence of intermediate-range ordering beyond the correlation between oxide polyhedron units in ZrO2upon melting.
DNA replication is accomplished by the replisome, a multi-protein complex that comprises the sliding clamp. Here, Moolman et al. present quantitative and dynamic measurements of the number of β2-sliding clamps at the single-cell level in live E. colicells to shed light on key aspects of DNA replication.
The hormone prolactin is a known modulator of mammalian lactation and hair growth. Here, the authors describe two dominant mutations in bovine prolactin and its receptor, demonstrating antagonistic effects on these traits and highlighting a role for this pathway in sweat gland function and thermoregulation.