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Here, the authors develop a graphene plasmonic infrared sensor to probe the secondary structure of nanoscale assembly intermediates and the morphological evolution of silk nanofibrils, the fundamental building blocks of silk fibres.
How folded proteins are translocated across membranes is unknown for eukaryotes. Here, the authors propose a concerted translocation mechanism used by the AAA-ATPase Bcs1 to retro-translocate fully folded Rieske iron-sulfur protein across mitochondrial inner membrane.
There are limited therapeutics available for treatment of mpox. In this study, the authors identify two non-competing human neutralizing monoclonal antibodies with protective effects against orthopoxvirus infection in a mouse model and structurally resolve the targeted epitope within the MPXV B6 protein.
Estimating weather-induced shocks on food production requires reliable global weather datasets. Here, the authors compare global (GMFD and ERA5-Land) and regional (PRISM) datasets, showing that global datasets can uncover non-linear temperature relationships despite their lower predictive skill.
AgRP neurons control appetite, but their transcriptional regulation remains a mystery. Here, the authors generate AgRP neuron transcriptional and chromatin accessibility profiles and show that IRF3 mediates the acute hunger-suppressing effects of leptin.
The precise cellular localization of the SARS-CoV-2 RNA and replication partners has been elusive. Here, the authors use super-resolution fluorescence microscopy and specific labeling to reveal the nanoscale structure of viral replication organelles.
Antifungal azoles inhibit ergosterol biosynthesis, but how that leads to fungistatic or fungicidal activities in many pathogenic fungi is poorly understood. Here, Schuster, Kilaru & Steinberg show that azole lethality in the plant pathogens Zymoseptoria tritici and Magnaporthe oryzae is due to a combination of reactive oxygen species-induced apoptosis and macroautophagy.
The relevance of post-translational modifications in pancreatic cancer remains insufficiently explored. Here, the authors report that ZDHHC20-mediated S-Palmitoylation of the m6A reader YTHDF3 stabilizes MYC mRNA to promote the progression of KRAS-mutant pancreatic cancer.
Zhang et al. propose the ecological status of the ocean by considering microbial diversity, structure, and biogeochemical potential. Ecological status of 32.44% surface ocean will change due to climate change in 2100, assuming no policy intervention.
On-chip optical sensing and metrology systems are rapidly progressing, but CMOS-compatible silicon light sources remain a challenge. This work demonstrates a broadband, foundry integrated silicon waveguide emitter and the theory that describes it.
Evolutionary models can help understand how the spatial arrangement of a population shapes its evolutionary dynamics. This study presents such a method and shows that the spatial architectures of stem cell populations in bone marrow are suppressors of selection, hinting at a potential evolutionary design.
Delay lines for quantum information are key for quantum networking and hardware efficient quantum computers. Here, the authors present a virtual delay line for microwave pulses where data is stored in the excitations of a collection of resonators, demonstrating translation and swapping of data pulses.
The authors report a zinc oxide resonant nano-accelerometer with sensitivity up to 16.818 kHz/g, which is attributed to the nano-resonators using zinc oxide nanowires and the optimized microleverages and push-pull structures.
Here, the authors develop Pangaea, an assembler that uses short-reads with long-range connectivity to create high-quality microbial genomes affordably, showing it outperforms existing methods in generating more complete genomes from both mock and real metagenomic samples.
Alternative stable states in forests have implications for the biosphere. Here, the authors combine forest biodiversity observations and simulations revealing that leaf types across temperate regions of the NH follow a bimodal distribution suggesting signatures of alternative forest states.
Pathologic α-synuclein spreads from cell-to-cell through binding to the lymphocyteactivation gene 3 (Lag3). Here, the authors demonstrate that the amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 and facilitates the binding, internalization, transmission, and toxicity of pathologic α-synuclein.
There is a lack of vaccines for prevention of human respirovirus 3 (RV3) infection. Bakkers et al. report the design of a stabilized RV3 preF protein vaccine candidate that induces strong neutralizing antibodies and protective responses in small animal models.
Biaryl compounds with an axial chirality are valuable architectures but few methods have been developed for the construction of bridged biaryls, a subclass of these compounds that bear a tether to connect the two arenes and form a medium-sized ring. Here, the authors design a Co/SPDO-catalyzed aerobic oxidative coupling/desymmetrization sequence of prochiral phenols for the enantioselective synthesis of biaxial bridged m-terphenyls embedded in an azocane.
The 2021 Pacific Northwest Heatwave challenged standard attribution methods. The authors use a weather model that predicted the event to quantify human impact on the heat, suggesting that such models could be used broadly to assess changing weather risk.
African swine fever virus is the sole mammalian-infecting virus encoding a type II topoisomerases (pP1192R). The authors present pP1192R structures in different states, illustrating the enzymatic mechanisms of viral type II topoisomerases.