With this collection, Nature Communications, Nature Medicine, Communications Medicine and Scientific Reports aim to publish research articles spanning the breadth of AMR and across microbial pathogens (bacteria, viruses, fungi and parasites). This includes, and is not limited to epidemiological monitoring of resistance incidence in clinical and environmental settings, novel strategies aiming to combat or prevent AMR (i.e. drug repurposing, drug synergy treatment, and vaccines), improvements in diagnostics, and subsequently tailored treatment, of drug-resistant infections.