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Antibody–peptide conjugates for targeted inhibition of cysteine proteases
We developed a rational approach to design peptide-based covalent inhibitors and coupled the inhibitors with antibodies for cell-specific delivery. We used this platform to generate antibody–peptide inhibitor conjugates (APICs) that target a family of proteases, the cysteine cathepsins. Our drug design and targeted delivery approach ensure specific inhibition and achieve therapeutic efficacy in different cancer cells and osteoclasts.
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Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins
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Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA
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Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting
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RNA-binding protein PTENα blocks RIG-I activation to prevent viral inflammation