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Ebrahimi and Samanta review the key advances in the chemical and structural modification of proteins that have enabled their rise as indispensable tools in medicine and outline emerging protein engineering strategies that can potentially unlock structures with improved therapeutic properties.
The lack of a standardized approach for the characterization of the performance of 2D photodetectors represents an important obstacle towards their industrialization. Here, the authors propose practical guidelines to characterize their figures of merit and analyse common situations where their performance can be misestimated.
In this Review article, the authors discuss the potential of microorganisms as a solution to the challenges faced by our food system. Engineered microorganisms can be used to produce enhanced foods and ingredients in a sustainable manner. The technical, economical, and societal limitations are also discussed together with the current and future perspectives.
Naturally evolved genomes tend to be unnecessarily large and redundant, and are not optimised for biotechnological or research applications. In this review, the authors explore genome minimization and re-functionalisation approaches, and discuss their potential for industrial applications.
Smartphone-based mobile health platforms have drawn increasing attention from researchers developing point-of-care testing devices. Here the authors summarize recent progress and future directions of approaches combining microfluidics and artificial intelligence.
Zooplankton are a critical link to higher trophic levels and play an important role in global biogeochemical cycles. This Review examines key responses of zooplankton to ocean warming, highlights key knowledge and geographic gaps that need to be addressed, and discusses how better use of observations and long-term zooplankton monitoring programmes can help fill these gaps.
Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation. PTM-regulated degrons act as signals for protein degradation or stabilization.
CRISPR-Cas tools have shown exceptional promise in genome engineering over the past decade. Here the authors review the development of CRISPR-Cas9/Cas12/Cas13 nucleases, DNA base editors, prime editors, and RNA base editors, as well as their editing precision, off-target effects, and clinical considerations.
While the contribution of sharp wave ripples in memory consolidation and decision-making is established in rodent models, our understanding of their role in human memory is incomplete. Here, the authors discuss common methodological challenges in detecting, analyzing, and reporting sharp wave ripples, then they suggest practical solutions to distinguish them from other high-frequency events
Microbots have attracted attention due to an ability to reach places and perform tasks which are not possible with conventional techniques in a wide range of applications. Here, the authors review the recent work in the field on the fabrication, application and actuation of 3D printed microbots offering a view of the direction of future microbot research.
The impact of fungal infections on human health has been exacerbated by the rise of antifungal drug resistance. In this Review, the authors outline the problem of antifungal resistance and suggest how this growing threat might be mitigated.
In this review, the authors look at how recent progress in single-cell transcriptomics complement and enrich the classical, largely morphological, portraits of fibroblasts. The detailed molecular information now available provides new insights into fibroblast identity, heterogeneity and function.
Deep learning has enabled advances in understanding biology. In this review, the authors outline advances, and limitations of deep learning in five broad areas and the future challenges for the biosciences.
In this Review, the authors discuss recent technological and neuroscientific advances in human body augmentation. They construct a movement augmentation taxonomy, discuss how it is achieved, and propose a vision for the field.
Large scale sustainable energy storage by water splitting benefits from performing the oxygen evolution reaction under a variety of conditions. Here, the authors discuss self-healing catalysis as a new tool in the design of stable and functionally active catalysts in acidic to basic solutions, and a variety of water sources
Transition-metal-catalyzed C–H arylations are an effective tool for the construction of biaryl motifs in an efficient and selective manner. Here the authors provide an overview of the state-of-the-art of the field and perspectives on emerging directions toward increased sustainability.
Synthetic DNA is the basis for promising technologies in data storage, barcoding, computing 62 and sercurity. In this review, the authors provide an overview of the field and its future.
New observations of volcanic and magmatic activity in Africa are changing our views of continental rifting and raising awareness of the associated hazards. However, despite a shift from crisis response to reducing disaster risks, limited capacity means mitigating geohazards remains challenging.
Cellular microbiology is a field that combines the study of infection and cell biology. In this review, we highlight emerging technologies and infection models that recently transformed our understanding of the infected cell and may inspire future medicine.
The high platinum loadings at the cathodes of proton exchange membrane fuel cells significantly contribute to the cost of these clean energy conversion devices. Here, the authors critically review and discuss recent developments on low- and non-platinum-based cathode catalysts and catalyst layers.