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Tactile sensors in human-machine interaction systems can provide precise input signals and the necessary feedback between humans and machines. Here, the authors developed a black phosphorous-based tactile sensor array system that can provide touch into audio feedback.
Mercury (Hg) concentrations and isotopes from terrestrial sections of southern Pangea provide evidence of the global volcanic effects of the Siberian Traps during the Permian-Triassic transition
How molecular diversity in neurons links to versatile functions is elusive. Here the authors profiled embryonic spinal motor neurons with single-cell RNAseq and identified molecular subtypes targeting distinct muscle groups in different species.
The biologically productive eastern boundary upwelling systems (EBUSs) are regarded as thermal refugia in a warming climate. However, the authors here show that Southern Hemisphere EBUSs are likely to become hotspots of future marine heatwaves.
The mitochondrial ATP synthase produces the bulk of cellular ATP. Here, the authors report a function of the mitochondrial Hsp70 in the formation of the catalytical head and in its assembly with the peripheral stalk to form the mature ATP synthase.
Coastal ecosystems are promoted as nature-based solutions to climate change. Here, the authors show that natural methane emissions across a variety of vegetated and unvegetated coastal habitats can, however, offset one-third of the carbon sink capacity attributed to atmospheric carbon dioxide uptake.
Sodium ion storage remains relatively unexplored in comparison with well-understood lithium ion storage mechanisms. Here, the authors systematically investigate the surface-redox sodium ion storage properties of anatase titanium dioxide, which delivers excellent rate capability, cycling stability and low overpotentials.
The lineage relationship between blood and endothelial cells has been difficult to examine due to the multiphasic timing of hematopoiesis in the embryo. Here the authors use using in vivo barcoding technology to assess cell ancestry and show that blood and endothelial cells emerge through common (haemangioblast) or separate (mesenchymoangioblasts and haematomesoblasts) progenitors in the yolk sac.
Cancer-associated fibroblasts (CAFs) are the main component of the stroma in pancreatic cancer, but their tissue of origin remains to be defined. Here the authors perform lineage tracing and single cell RNA sequencing in mice and suggest the splanchnic mesenchyme as the tissue of origin for CAFs.
Fragility describes the sharpness of dynamical arrest of a melt at its glass transition, yet its structural origin remains elusive. Shi et al. show that fragility inversely correlates with the medium-range order structure characterized by a measurable parameter named the average medium-range distance.
Utilizing the Marangoni effect, miniaturized machineries can be endowed with self-propulsion. Here, the authors report high-performance Marangoni hydrogel rotors with asymmetric porosity and drag reduction profile and demonstrate multiple potential functionalities.
Low-cost targeted approach to construct haplotype-resolved assemblies is needed to facilitate population genetic studies. Here, the authors demonstrate assembling high-quality MHC haplotypes with CRISPR-based enrichment and long-read sequencings.
Macrophages have been reported to regulate thermogenic, sympathetic neuron-mediated norepinephrine signaling in adipose tissues. Here the authors report that male mice lacking the allograft inflammatory factor-1 protein are resistant to diet-induced obesity, in association with higher adipose norepinephrine levels and lower expression of the norepinephrine catabolic enzyme monoamine oxidase A.
Exploring two-dimensional layered ferroelectric semiconductors is highly desired for ferroelectric-based devices. Here, the authors realize the room-temperature ferroelectricity in layered Y-doped γ-InSe due to the microstructure modifications.
Immune checkpoint inhibitors and antiangiogenic agents have shown some activity in patients with late-stage gastric cancer. Here the authors report the results of a phase II trial of neoadjuvant anti-PD1 (camrelizumab), antiangiogenic agent (apatinib), and chemotherapy (S-1 ± Oxaliplatin) in stage T4a/bN + M0 gastric cancer patients.
pH sensation is critical for survival of vertebrates. Here, authors found six vertebrate OTOP1 channels that were highly conserved and directly activated by extracellular alkali. Key mutations of OTOP1 reduced alkali affinity without affecting acid activation.
Injury poses heavy burden on public health, but little evidence on the potential role of climate change on injury exists. Here, the authors collect data during 2013-2019 in six provinces of China to estimate the associations between temperature and injury mortality, and to project future mortality burden attributable to temperature change driven by climate change.