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Encoding and downsampling images is key for visual prostheses. Here, the authors show that an actor-model framework using the inherent computation of the retinal network yields better performance in downsampling images compared to learning-free methods.
It is desirable to be able to mimic the properties of skin with hydrogels, but challenging to achieve. Here, the authors report the use of functionalised extracellular vesicles as crosslinkers for skin-mimicking hydrogels with good mechanical strength.
Dysregulated autophagy and mitochondrial function are two well-described hallmarks of aging. Here, the authors describe an unexpected age-associated upregulation of mitophagy in response to neuroinflammation triggered by leaked mtDNA.
Surgery is a primary therapeutic modality for treating melanoma, but it is challenging to tackle tumor recurrence/metastasis and postsurgical wounds. Here the authors report a sprayable hydrogel capable of long-lasting and controllable oxygen supply for preventing tumor recurrence/metastasis and simultaneously promoting wound healing during the postsurgical treatment of melanoma.
Recent work has demonstrated the potential of polycrystalIine antiferromagnetic materials for spintronics. Here the authors report evidence of magnetic phase transitions in a polycrystalline non-collinear antiferromagnet, which are explained by a phenomenological model with topological orbital momenta.
The authors present two independent reconstructions and a model simulations of Atlantic hurricane activity over the last millennium and show that it is mainly driven by internal climate variability instead of external forcings.
Soil organisms are affected by the presence of predatory protists. Here, the authors predatory protists are negatively associated with bacteria wilt disease incidence in tomato plants and that fertilisation enhances the abundance of predatory protists
It is unclear whether naturally evolved de novo proteins have stable, folded structures. Here, through systematic identification and structural modeling of de novo genes, this study reveals that a small subset of these proteins may have well-folded structures, and were likely born with these structures.
Caloric restriction (CR) has been demonstrated to have a role in tumour growth and therapy response but its effects on cancer stem cells are less known. Here, in Acute Promyelocytic Leukemia, the authors show that despite initial anti-tumour effect, CR drives the selection of leukaemia-initiating cells resulting in relapse which could be prevented by ablation of LSD1.
Increasing rainfall intensity produces opposite hydrological effects across a large river basin in South China (drying in the uplands vs. wetting in the lowlands) due to spatially contrasting interactions between rainfall intensification and topography.
Nutrient limitation is a well-known control of phytoplankton growth, but predicting specific responses in individual lakes based on nutrient data alone has proven challenging. Here, the authors show that long-term signals of chlorophyll-a dynamics in shallow lakes can be captured based on stoichiometric effects of N and P concentrations along a continuum of total N:total P ratios.
Inspired by insects in nature, the authors develop a neuromorphic robotic system with obstacle avoidance, tunnel centering and gap crossing capabilities. Their robotic system accomplishes these multiple capabilities by steering towards regions of low apparent motion.
Whether Kupffer cells play a role in regulating the pathogenesis of fatty liver disease remains to be completely explored. Here, the authors show GPR3 activation stimulates glycolysis in Kupffer cells through GPR3-β-arrestin2-GAPDHPKM2 pathway and inhibits high-fat diet induced obesity and liver pathogenesis.
In this work, the authors report the full-length structure of the attachment glycoprotein from Langya Henipavirus, which could enhance the understanding of emerging Henipavirus and provide important clues for vaccine development in the future.
Challenges in reproducibility and large-scale expansion limit the current applicability of human intestinal organoids. Here, the authors present a feeder-free, chemically-defined culture method for enrichment of intestinal stem cells isolated from 3D human intestinal organoids.
Li–CO2 batteries following Li2CO3-product route suffers from low output voltage and severe parasitic reactions. Here, the authors introduce a copper-based solid redox mediator in Li–CO2 batteries with an efficient Li2C2O4 product route to circumvent the shuttle effect and sluggish kinetics caused by soluble mediators.
Plant antagonists may disrupt the allocation of carbon resources from plants to mutualistic microorganisms. Here, the authors report how plants attacked by cyst nematodes and aphids maintain carbon transfer to arbuscular mycorrhizal fungi through fatty acid transfer whilst the limiting the loss of sugars.
Different approaches have been described for the transdermal delivery of drugs. Here the authors report the design of a fluorocarbon modified chitosan-based non-invasive transdermal platform for the delivery of biomacromolecules, such as viral antigens for vaccines or immune checkpoint inhibitors for melanoma immunotherapy.
The cellular origin of human pancreatic ductal adenocarcinoma (PDAC) is still unclear. Here the authors used human primary acinar and ductal cells to successfully reconstitute PDAC tumorigenesis from both lineages and revealed transcriptional changes during early PDAC progression.
Lightweight flexible piezoelectric polymers are demanded for various applications, but restricted by the low instinctively piezoelectric coefficient and complex poling process. Here, the authors develop a high performance lightweight, flexible self-poled piezoelectric polymer composite towards sustainable self-powered sensing and energy harvesting.