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Incorporating spin crossover motifs into mechanically interlocked molecules offers various switchable properties. Here, the authors report two FeII catenated metal-organic frameworks that exhibit spin dependent luminescence and dielectric switching.
Supramolecular polymer networks have unique and useful properties due to the reversible nature of their cross-links. Here, the authors show that when two distinct supramolecular interaction classes exist within a single cross-link, new functions can result.
Hepatocytes are central for maintaining metabolic homeostasis during nutritional transitions. Here, we show that the structural remodelling of hepatic organelles is part of hepatocytes’ metabolic plasticity to adapt to cycles of fasting/feeding and this process is zonated in the liver.
Here the authors unveil an intermediate state during the folding of the manganese riboswitch from L. lactis. This transient state allows the integration of multiple cellular signals including RNA polymerase pausing and transcription factor NusA.
The defense-associated sirtuin 2 (DSR2) system protects bacteria from phages by depleting NAD+. Here, authors elucidate the molecular mechanisms underlying DSR2 assembly, activation, and inhibition, providing important insights into bacterial anti-phage defense.
Authors predict polar Bloch points with negative capacitance in tensile-strained ultrathin ferroelectric PbTiO3 film by phase-field simulations, observing their polarization structures by scanning transmission electron microscopic imaging.
Efficient milk production in mammals confers advantages by facilitating the transmission of energy from mother to offspring. However, the factors for establishing the efficiency in mammals are unknown. Here, the authors identify FUS as a regulator of efficient milk production in mammals.
Recently, various computational tools have emerged for detecting mRNA isoforms using long-read sequencing data. Here, the authors systemically evaluate and compare the performance of these tools.
Whether prediction errors are encoded by synergistic information across the cortex is unknown. Here, the authors demonstrate that distributed representations of prediction errors across the cortex can be highly synergistic.
Wang et al. report large nonvolatile polarization in stretchable polymer ferroelectrics incorporating perovskite nanocrystals. The built-in electric field from poled ferroelectrics stabilises Frenkel defects via interfacial coupling, which can also enhance the polarization of nonferroelectrics.
High levels of extended spectrum beta-lactamase (ESBL) and carbapenemase encoding genes were detected in bacterial isolates causing neonatal sepsis in LMICs. Authors assess the in vitro activity of three antibiotics (fosfomycin, flomoxef and amikacin) in combination against ESBL-producing Klebsiella pneumoniae and Escherichia coli isolates.
Encephalitis is a rare and severe complication of Herpes Simplex type 1 infection. Here, Bibert et al describe a genetic variant in a 2-year-old affected child that impairs interferon production in neuronal cells and enhances viral replication.
Immunopeptidomics is crucial for the discovery of potential immunotherapy and vaccine candidates. Here, the authors generate a ground truth timsTOF dataset to fine-tune the deep learning model Prosit, improving peptide-spectrum match rescoring by up to 3-fold during immunopeptide identification.
Conventional material processing methods often suffer by strength-ductility trade-off. Here, the authors show high-pressure and high-temperature treatment can transform an eutectic high entropy alloy to having a hierarchical microstructure with simultaneous enhancements of strength and ductility.
A-to-I editing in animals is catalyzed by enzymes of the Adenosine Deaminase Acting on RNA family, orthologues of which do not exist in fungi. Here, Feng et al. characterise the enzymes involved in A-to-I mRNA editing in Fusarium graminearum.
Limited experimental platforms exist for assessing quantitative sequence-function relationships for multiple antibodies. Here, authors develop a deep-sequencing based technology called MAGMA-seq, that determines the quantitative properties of antibody libraries.
Assumptions about the use of biomass and CO2 sequestration drive key differences in how emissions from remaining fuels are mitigated in net-zero energy systems, with potentially significant tradeoffs that will need to be evaluated and managed.
It has been previously suggested that STING agonists can improve response to CAR-T therapy. Here the authors report the characterization of the STING agonist IMSA101, showing that STING-induced IL18 secretion enhances CAR-T activity in preclinical cancer models.
Inspired by the biologics of hematophagous organisms such as leeches, the authors in this work design and create inhibtors of thrombin and factor Xa by linking exosite-binding aptamers with small molecule active site inhibtors. They coin these inhibitors EXACT inhibitors.
Significant efforts have been dedicated to understanding the mechanisms of decoherence in superconducting qubits. Here, using time-resolved error measurements, the authors link errors present in transmon qubits based on Nb electrodes to mechanical vibrations of a commonly used pulse tube cooler.