Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Millirobots effective application generally depends on cost, scalability, efficient locomotion, and the ability to track target trajectory precisely. Here, authors demonstrate promising graphene-based helical millirobots by introducing asymmetric light pattern distortion to a laser-induced graphene process.
α,β-unsaturated compounds serve as versatile synthons in organic chemistry, but the α,β-desaturation of aliphatic imines is challenging due to easy hydrolysis and preferential dimerization. Herein, the authors report the synthesis of α,β-unsaturated imines by employing a pre-fluorination and palladium-catalyzed dehydrogenation reaction sequence.
How the cortex forms spatially structured modules during development is poorly understood. Here, the authors show that activity in early developing cortex is self-organized though local-excitation and lateral inhibition.
While it is known that localised prostate cancer is characterised by clonal heterogeneity, the clonal origin of synchronous lymph node (LN) metastases remains poorly understood. Here, the authors analyse the clonal origin of LN metastases in prostate cancer patients using multi-region sequencing.
The evolution of feathers is associated with the evolution of related skin microstructures. Here, the authors demonstrate that Psittacosaurus, a non-avian feathered dinosaur, retained scaled skin like its ancestors in body regions lacking feathers.
The regulatory mechanism and function of astrocytic epigenetic effects on depression remain to be explored. Here, the authors show astrocytic ALKBH5 contributes to depressive-like behaviors via the m6A RNA methylation of GLT-1.
Here, authors classify genes flanking the Heliorhodopsin (HeR)-encoding genes and identify highly conserved residues for protein–protein interactions, revealing a function of HeR as regulatory rhodopsin for multidrug resistance.
Néel spin-orbit torques arise due to charge currents in some antiferromagnets, and have sparked interest as a possible pathway for achieving electrical control of antiferromagnetic order. While the driving of antiferromagnetic order by Néel spin-orbit torques is now experimentally well established, the inverse process, where magnetic excitations in an antiferromagnetic drive a charge current is not reported. Here Huang, Liao, Qiu, and coauthors observe this inverse process in an Mn2Au thin film.
Protein corona formation on the surface of liposome nanocarriers can decrease the efficiency of intracellular delivery. Here, the authors develop antifouling membrane-fusogenic liposomes for effective intracellular delivery in vivo.
Preventive interventions often require strategies to identify high-risk individuals. Here, the authors illustrate the potential utility of medical history in predicting the onset risk for thousands of diseases across clinical specialties including COVID-19.
Data-driven detection of governing rules and trends in dynamics of nonautonomous systems usually requires a significant amount of measured data. The authors propose an operator-theoretic technique for identifying trends and persistent cycles using data from a single measured trajectory, relevant for the analysis of climate dynamics.
Adhesives require a balance between cohesion and interfacial adhesion, which can be challenging to achieve. Here the authors report the polymerisation of a protic ionic liquid-based monomer, with internal and external non-covalent interactions contributing to both cohesion and adhesion.
Amino acids availability is normally a limitation for protein synthesis and can determine cancer progression and therapy response. Here, the authors show that MYC-associated cancer has a dependency on tryptophan not because of translation regulation, but Indole 3-Pyruvate synthesis.
Identifying biomarkers associated with risk of severe COVID-19 disease could inform clinical management. Here, the authors identify a long noncoding RNA associated with severe disease using data from three European countries, and validate their finding in data from Canada.
Individuals differ in how they weight probability and reward information when making risky choices. Here, the authors use magnetoencephalography to test whether such variation is related to how information is neurally represented during choice evaluation.
Traditional scintillators face challenges in achieving fast response and avoiding afterglow. Guzelturk et al. report colloidal quantum shell heterostructures with bright multiexciton emission, enabling efficient, fast, and robust scintillation for high-resolution and high-speed X-ray imaging.
Here the authors identify PCNA, a master regulator of DNA replication, as a ubiquitin substrate for the BRCA1/BARD1 heterodimer. This modification is crucial to avoid the appearance of unreplicated DNA gaps in the genome after replication.
Heart failure is characterised by a detrimental rise in the intracellular sodium concentration. Here the authors show that this reversibly reprogrammes energy metabolism in the heart making this a possible therapeutic target for the development of new drugs.
This study uses cryo-EM, biochemical, and computational approaches to shed light on the fundamental mechanisms underlying the human mitoribosome function, including ligand binding, modifications, Fe-S clusters, and aging-related polyamines.
Ferroptosis is a form of cell death that has been associated with different diseases. Here the authors describe an association of ferroptosis with COVID-19 pulmonary pathologies in both patient samples and hamster model and suggest that the dysregulation in iron and lipid metabolism could provide targets to reduce pathology.