Whole genome amplification

Whole genome amplification is a method for generating many copies of an entire genome for downstream applications such as sequencing when starting material is limited.

Latest Research and Reviews

Research | 15 February 2019 | open

Single gametophyte sequencing reveals that crossover events differ between sexes in maize

Meiotic crossover (CO) landscape differs inter- and intra-species, as well as between sexes. Here, the authors show that male meiosis produces more COs than female in maize and detect CO maturation inefficiency in some genetic backgrounds, which may help to improve breeding efficiency.
- Cheng Luo
- , Xiang Li
- , Qinghua Zhang
- & Jianbing Yan
Nature Communications 10, 785
Research | 10 May 2018 | open

Exploring DNA quality of single cells for genome analysis with simultaneous whole-genome amplification
- Christiane Bäumer
- , Evelyn Fisch
- , Holger Wedler
- , Frank Reinecke
- & Christian Korfhage
Scientific Reports 8, 7476
Protocols | 29 March 2018

The successes and future prospects of the linear antisense RNA amplification methodology

This Perspective discusses the development of the linear amplified RNA amplification technique over the last 25 years, and future applications of this important and versatile methodology.
- Jifen Li
- & James Eberwine
Nature Protocols 13, 811-818
Research | 01 February 2018 | open

Obtaining high-quality draft genomes from uncultured microbes by cleaning and co-assembly of single-cell amplified genomes
- Masato Kogawa
- , Masahito Hosokawa
- , Yohei Nishikawa
- , Kazuki Mori
- & Haruko Takeyama
Scientific Reports 8, 2059
Research | 12 July 2017 | open

Massively parallel whole genome amplification for single-cell sequencing using droplet microfluidics
- Masahito Hosokawa
- , Yohei Nishikawa
- , Masato Kogawa
- & Haruko Takeyama
Scientific Reports 7, 5199
Research | 23 June 2017 | open

Efficient and unbiased metagenomic recovery of RNA virus genomes from human plasma samples
- Carmen F. Manso
- , David F. Bibby
- & Jean L. Mbisa
Scientific Reports 7, 4173

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News and Comment

Research Highlights | 30 October 2018

Diploid genome in 3D

Dip-C, a descendent of the 3C method, reveals 3D genome structures of single diploid human cells.
- Lei Tang
Nature Methods 15, 858
News | 05 June 2017

Genome watch: Klebsiella pneumoniae: when a colonizer turns bad

This month's Genome Watch highlights how whole-genome sequencing (WGS) and epidemiological studies can be combined to explore the link between colonization and infection by Klebsiella pneumoniae in patients who are hospitalised.
- Matthew J. Dorman
- & Francesca L. Short
Nature Reviews Microbiology 15, 384
Research Highlights | 16 August 2016

Technology: Enabling accurate single-cell genome amplification
- Darren J. Burgess
Nature Reviews Genetics 17, 503
Research Highlights | 28 April 2016

Neuroscience: Mutational burden of neurons

Nature Methods 13, 395
Research Highlights | 29 October 2015

Genomics: Single-cell DNA amplification gets even

Nature Methods 12, 1009
Research Highlights | 26 February 2015

Sequencing: The genome and transcriptome of a single cell

Nature Methods 12, 173

All News & Comment

Whole genome amplification

Latest Research and Reviews

Single gametophyte sequencing reveals that crossover events differ between sexes in maize

Exploring DNA quality of single cells for genome analysis with simultaneous whole-genome amplification

The successes and future prospects of the linear antisense RNA amplification methodology

Obtaining high-quality draft genomes from uncultured microbes by cleaning and co-assembly of single-cell amplified genomes

Massively parallel whole genome amplification for single-cell sequencing using droplet microfluidics

Efficient and unbiased metagenomic recovery of RNA virus genomes from human plasma samples

News and Comment

Diploid genome in 3D

Genome watch: Klebsiella pneumoniae: when a colonizer turns bad

Technology: Enabling accurate single-cell genome amplification

Neuroscience: Mutational burden of neurons

Genomics: Single-cell DNA amplification gets even

Sequencing: The genome and transcriptome of a single cell

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Whole genome amplification

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