Featured
-
-
Article |
Fast optical recording of neuronal activity by three-dimensional custom-access serial holography
3D-CASH is a random-access microscopy approach that avoids in vivo motion artifacts by sampling each targeted neuron with a holographically shaped grid of illumination spots. The technology allows recording neuronal activity in the mouse cortex at a throughput of 20,000 neurons per second.
- Walther Akemann
- , Sébastien Wolf
- & Laurent Bourdieu
-
Article |
Chronically implantable LED arrays for behavioral optogenetics in primates
An implantable array of LEDs called the Opto-Array facilitates optogenetic manipulations in the nonhuman primate brain.
- Rishi Rajalingham
- , Michael Sorenson
- & Arash Afraz
-
Brief Communication |
Kilohertz two-photon fluorescence microscopy imaging of neural activity in vivo
High-speed two-photon laser scanning microscopy using a passive laser scanner based on free-space angular-chirp-enhanced delay achieves frame rates suitable for voltage imaging in vivo in the mouse brain.
- Jianglai Wu
- , Yajie Liang
- & Na Ji
-
-
-
-
Article |
Kilohertz frame-rate two-photon tomography
A two-photon computed tomography approach, called scanned line angular projection microscopy, enables high-speed imaging at over 1 kHz frame rates, as demonstrated for glutamate imaging in the in vivo mouse brain.
- Abbas Kazemipour
- , Ondrej Novak
- & Kaspar Podgorski
-
Research Highlight |
Sequence meets space
A new computational method integrates RNA single-cell sequencing and spatial data.
- Tal Nawy
-
Methods in Brief |
Mice at the steering wheel
-
Article |
Virtual reality for freely moving animals
FreemoVR is a virtual reality system for freely moving animals. The versatile platform is demonstrated in various experiments with Drosophila, zebrafish, and mice.
- John R Stowers
- , Maximilian Hofbauer
- & Andrew D Straw
-
Research Highlights |
Connectomics at the single-cell level
Trans-synaptic tracing that starts from a single neuron provides a detailed view of that neuron's inputs.
- Nina Vogt
-
Methods in Brief |
Adapting to aberrations in brain imaging
-
Correspondence |
Whole-brain functional imaging with two-photon light-sheet microscopy
- Sébastien Wolf
- , Willy Supatto
- & Raphaël Candelier
-
Tools in Brief |
Pinpointing postsynaptic partners
-
Research Highlights |
Optical inhibition in red
The red light–sensitive optogenetic inhibitor Jaws enables the modulation of neural activity deep inside the brain.
- Nina Vogt
-
Methods in Brief |
Keeping an eye on the retina
-
Correspondence |
Light-sheet functional imaging in fictively behaving zebrafish
- Nikita Vladimirov
- , Yu Mu
- & Misha B Ahrens
-
Methods in Brief |
Cell type–specific synaptic labeling
-
Research Highlights |
A tool belt for GFP
Nanobodies turn any GFP-expressing cells into targets for in vivo functional manipulation.
- Tal Nawy
-
News & Views |
Watching the fly brain in action
New technical feats make it possible to monitor the activity of identified neurons in awake behaving Drosophila melanogaster.
- Damon A Clark
- , Saskia E J de Vries
- & Thomas R Clandinin
Light-Seq: light-directed in situ barcoding of biomolecules in fixed cells and tissues for spatially indexed sequencing