Systems virology articles from across Nature Portfolio

The diversity and impact of viruses in remote marine environments are less well understood. In this study, the authors analyse an -omics dataset to gain insights into the genomics and potential role of endemic viruses infecting ecologically important microbes inhabiting the ocean cavity beneath the Ross Ice Shelf.

A host-viral interactome map demonstrates that turnip mosaic virus targets high information-spreading nodes, which are also hubs.

A pseudotime analysis of the host cell response to SARS-CoV-2 infection using publicly available scRNA-seq data derived from in vitro studies reveals a non-lineal, triphasic transcriptional response and suggests a global regulatory mechanism.

Zika virus (ZIKV) infection suppresses the induction of dendritic cell (DC)-derived immunity, but the underlying mechanistical insights are still lacking. Here the authors show, using in vitro systems profiling of DC transcriptome and epigenome, that ZIKV specifically alters SREBP2-related expression of inflammation- and metabolism-related genes to modulate DC functions.

Master Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model.

This month's Genome Watch highlights a new large-scale serological platform for the simultaneous detection of multiple human viruses in a single drop of blood.

A study in transplant recipients shows that virome composition and size depends on immunocompetence.

Ultra-deep sequencing of the gut virome reveals rapid evolution of phage populations in an individual host.