Viral membrane fusion

Definition

Viral membrane fusion is the process by which enveloped viruses enter host cells. It involves the merging (fusion) of the virus membrane with the host cell membrane or at an intracellular location following virus uptake by endocytosis. Fusion is mediated by transmembrane proteins that are anchored on the virus surface.

Latest Research and Reviews

  • Research | | open

    An efficient vaccine for human metapneumovirus (hMPV) will likely rely on neutralizing antibodies against the fusion protein (F). Here, the authors determine the crystal structure of pre-fusion-stabilized hMPV F and identify a dense glycan shield that affects generation of neutralizing antibodies.

    • Michael B. Battles
    • , Vicente Más
    • , Eduardo Olmedillas
    • , Olga Cano
    • , Mónica Vázquez
    • , Laura Rodríguez
    • , José A. Melero
    •  & Jason S. McLellan
  • Research |

    New high-resolution cryo-electron microscopy structures of the HIV-1 envelope protein provide a detailed description and understanding of how the HIV-1 fusion machinery functions and how it changes its structure over time to convert from the pre-fusion to the fusion-intermediate conformation.

    • Gabriel Ozorowski
    • , Jesper Pallesen
    • , Natalia de Val
    • , Dmitry Lyumkis
    • , Christopher A. Cottrell
    • , Jonathan L. Torres
    • , Jeffrey Copps
    • , Robyn L. Stanfield
    • , Albert Cupo
    • , Pavel Pugach
    • , John P. Moore
    • , Ian A. Wilson
    •  & Andrew B. Ward
    Nature 547, 360–363
  • Research |

    Cryo-EM and mass spectrometry analyses of the spike glycoprotein trimer from coronavirus HcoV-NL63 reveal an extensive glycan shield that covers the protein surface, including an epitope targeted by neutralizing antibodies against several coronaviruses.

    • Alexandra C Walls
    • , M Alejandra Tortorici
    • , Brandon Frenz
    • , Joost Snijder
    • , Wentao Li
    • , Félix A Rey
    • , Frank DiMaio
    • , Berend-Jan Bosch
    •  & David Veesler
  • Research |

    The crystal structure of the GP1–GP2 complex of the prototypical arenavirus LCMV in prefusion form sheds light on the conformational changes that the arenavirus glycoprotein undergoes to cause fusion.

    • Kathryn M Hastie
    • , Sébastien Igonet
    • , Brian M Sullivan
    • , Pierre Legrand
    • , Michelle A Zandonatti
    • , James E Robinson
    • , Robert F Garry
    • , Félix A Rey
    • , Michael B Oldstone
    •  & Erica Ollmann Saphire
  • Research |

    The high-resolution cryo-electron microscopy structure of a pre-fusion coronavirus spike trimer from mouse hepatitis virus is presented; the structure reveals architectural similarities to paramyxovirus F proteins, suggesting that these fusion proteins may have evolved from a distant common ancestor.

    • Alexandra C. Walls
    • , M. Alejandra Tortorici
    • , Berend-Jan Bosch
    • , Brandon Frenz
    • , Peter J. M. Rottier
    • , Frank DiMaio
    • , Félix A. Rey
    •  & David Veesler
    Nature 531, 114–117

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